Cyclic nucleotide-gated cation channel alpha-3 (Cone photoreceptor cGMP-gated channel subunit alpha) (Cyclic nucleotide-gated channel alpha-3) (CNG channel alpha-3) (CNG-3) (CNG3)
1_MAKIN 6_ TQYSH 11_ PSRTH 16_ LKVKT 21_ SDRDL 26_ NRAEN 31_ GLSRA 36_ HSSSE 41_ ETSSV 46_ LQPGI 51_ AMETR 56_ GLADS 61_ GQGSF 66_ TGQGI 71_ ARLSR 76_ LIFLL 81_ RRWAA 86_ RHVHH 91_ QDQGP 96_ DSFPD 101_ RFRGA 106_ ELKEV 111_ SSQES 116_ NAQAN 121_ VGSQE 126_ PADRG 131_ RSAWP 136_ LAKCN 141_ TNTSN 146_ NTEEE 151_ KKTKK 156_ KDAIV 161_ VDPSS 166_ NLYYR 171_ WLTAI 176_ ALPVF 181_ YNWYL 186_ LICRA 191_ CFDEL 196_ QSEYL 201_ MLWLV 206_ LDYSA 211_ DVLYV 216_ LDVLV 221_ RARTG 226_ FLEQG 231_ LMVSD 236_ TNRLW 241_ QHYKT 246_ TTQFK 251_ LDVLS 256_ LVPTD 261_ LAYLK 266_ VGTNY 271_ PEVRF 276_ NRLLK 281_ FSRLF 286_ EFFDR 291_ TETRT 296_ NYPNM 301_ FRIGN 306_ LVLYI 311_ LIIIH 316_ WNACI 321_ YFAIS 326_ KFIGF 331_ GTDSW 336_ VYPNI 341_ SIPEH 346_ GRLSR 351_ KYIYS 356_ LYWST 361_ LTLTT 366_ IGETP 371_ PPVKD 376_ EEYLF 381_ VVVDF 386_ LVGVL 391_ IFATI 396_ VGNVG 401_ SMISN 406_ MNASR 411_ AEFQA 416_ KIDSI 421_ KQYMQ 426_ FRKVT 431_ KDLET 436_ RVIRW 441_ FDYLW 446_ ANKKT 451_ VDEKE 456_ VLKSL 461_ PDKLK 466_ AEIAI 471_ NVHLD 476_ TLKKV 481_ RIFQD 486_ CEAGL 491_ LVELV 496_ LKLRP 501_ TVFSP 506_ GDYIC 511_ KKGDI 516_ GKEMY 521_ IINEG 526_ KLAVV 531_ ADDGV 536_ TQFVV 541_ LSDGS 546_ YFGEI 551_ SILNI 556_ KGSKS 561_ GNRRT 566_ ANIRS 571_ IGYSD 576_ LFCLS 581_ KDDLM 586_ EALTE 591_ YPEAK 596_ KALEE 601_ KGRQI 606_ LMKDN 611_ LIDEE 616_ LARAG 621_ ADPKD 626_ LEEKV 631_ EQLGS 636_ SLDTL 641_ QTRFA 646_ RLLAE 651_ YNATQ 656_ MKMKQ 661_ RLSQL 666_ ESQVK 671_ GGGDK 676_ PLADG 681_ EVPGD 686_ATKTE
1: Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (PubMed:10888875, PubMed:12815043, PubMed:34969976, PubMed:37463923). Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. In the taste buds, may sense oral extracellular pH and conduct ion currents that modulate the excitability of taste cells (By similarity). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations (By similarity) (PubMed:12815043)