Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)
1_MNPFQ 6_ KNESK 11_ ETLFS 16_ PVSIE 21_ EVPPR 26_ PPSPP 31_ KKPSP 36_ TICGS 41_ NYPLS 46_ IAFIV 51_ VNEFC 56_ ERFSY 61_ YGMKA 66_ VLILY 71_ FLYFL 76_ HWNED 81_ TSTSI 86_ YHAFS 91_ SLCYF 96_ TPILG 101_ AAIAD 106_ SWLGK 111_ FKTII 116_ YLSLV 121_ YVLGH 126_ VIKSL 131_ GALPI 136_ LGGQV 141_ VHTVL 146_ SLIGL 151_ SLIAL 156_ GTGGI 161_ KPCVA 166_ AFGGD 171_ QFEEK 176_ HAEER 181_ TRYFS 186_ VFYLS 191_ INAGS 196_ LISTF 201_ ITPML 206_ RGDVQ 211_ CFGED 216_ CYALA 221_ FGVPG 226_ LLMVI 231_ ALVVF 236_ AMGSK 241_ IYNKP 246_ PPEGN 251_ IVAQV 256_ FKCIW 261_ FAISN 266_ RFKNR 271_ SGDIP 276_ KRQHW 281_ LDWAA 286_ EKYPK 291_ QLIMD 296_ VKALT 301_ RVLFL 306_ YIPLP 311_ MFWAL 316_ LDQQG 321_ SRWTL 326_ QAIRM 331_ NRNLG 336_ FFVLQ 341_ PDQMQ 346_ VLNPL 351_ LVLIF 356_ IPLFD 361_ FVIYR 366_ LVSKC 371_ GINFS 376_ SLRKM 381_ AVGMI 386_ LACLA 391_ FAVAA 396_ AVEIK 401_ INEMA 406_ PAQPG 411_ PQEVF 416_ LQVLN 421_ LADDE 426_ VKVTV 431_ VGNEN 436_ NSLLI 441_ ESIKS 446_ FQKTP 451_ HYSKL 456_ HLKTK 461_ SQDFH 466_ FHLKY 471_ HNLSL 476_ YTEHS 481_ VQEKN 486_ WYSLV 491_ IREDG 496_ NSISS 501_ MMVKD 506_ TESRT 511_ TNGMT 516_ TVRFV 521_ NTLHK 526_ DVNIS 531_ LSTDT 536_ SLNVG 541_ EDYGV 546_ SAYRT 551_ VQRGE 556_ YPAVH 561_ CRTED 566_ KNFSL 571_ NLGLL 576_ DFGAA 581_ YLFVI 586_ TNNTN 591_ QGLQA 596_ WKIED 601_ IPANK 606_ MSIAW 611_ QLPQY 616_ ALVTA 621_ GEVMF 626_ SVTGL 631_ EFSYS 636_ QAPSS 641_ MKSVL 646_ QAAWL 651_ LTIAV 656_ GNIIV 661_ LVVAQ 666_ FSGLV 671_ QWAEF 676_ ILFSC 681_ LLLVI 686_ CLIFS 691_ IMGYY 696_ YVPVK 701_ TEDMR 706_ GPADK 711_ HIPHI 716_ QGNMI 721_KLETK
1: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:16434549, PubMed:18367661, PubMed:7756356). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed:7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:20406817)