Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6)
1_MASSL 6_ PWLCI 11_ ILWLE 16_ NALGK 21_ LEVEG 26_ NFYSE 31_ NVSRI 36_ LDNLL 41_ EGYDN 46_ RLRPG 51_ FGGAV 56_ TEVKT 61_ DIYVT 66_ SFGPV 71_ SDVEM 76_ EYTMD 81_ VFFRQ 86_ TWTDE 91_ RLKFG 96_ GPTEI 101_ LSLNN 106_ LMVSK 111_ IWTPD 116_ TFFRN 121_ GKKSI 126_ AHNMT 131_ TPNKL 136_ FRIMQ 141_ NGTIL 146_ YTMRL 151_ TINAD 156_ CPMRL 161_ VNFPM 166_ DGHAC 171_ PLKFG 176_ SYAYP 181_ KSEII 186_ YTWKK 191_ GPLYS 196_ VEVPE 201_ ESSSL 206_ LQYDL 211_ IGQTV 216_ SSETI 221_ KSNTG 226_ EYVIM 231_ TVYFH 236_ LQRKM 241_ GYFMI 246_ QIYTP 251_ CIMTV 256_ ILSQV 261_ SFWIN 266_ KESVP 271_ ARTVF 276_ GITTV 281_ LTMTT 286_ LSISA 291_ RHSLP 296_ KVSYA 301_ TAMDW 306_ FIAVC 311_ FAFVF 316_ SALIE 321_ FAAVN 326_ YFTNL 331_ QTQKA 336_ KRKAQ 341_ FAAPP 346_ TVTIS 351_ KATEP 356_ LEAEI 361_ VLHPD 366_ SKYHL 371_ KKRIT 376_ SLSLP 381_ IVSSS 386_ EANKV 391_ LTRAP 396_ ILQST 401_ PVTPP 406_ PLSPA 411_ FGGTS 416_ KIDQY 421_ SRILF 426_ PVAFA 431_ GFNLV 436_ YWVVY 441_ LSKDT 446_MEVSS
1: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:8632757). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (PubMed:8632757). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition. Alpha-6 subunits are also present on glutamatergic synapses (By similarity)