Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
1_MASDA 6_ VQSEP 11_ RSWSL 16_ LEQLG 21_ LAGAD 26_ LAAPG 31_ VQQQL 36_ ELERE 41_ RLRRE 46_ IRKEL 51_ KLKEG 56_ AENLR 61_ RATTD 66_ LGRSL 71_ GPVEL 76_ LLRGS 81_ SRRLD 86_ LLHQQ 91_ LQELH 96_ AHVVL 101_ PDPAA 106_ THDGP 111_ QSPGA 116_ GGPTC 121_ SATNL 126_ SRVAG 131_ LEKQL 136_ AIELK 141_ VKQGA 146_ ENMIQ 151_ TYSNG 156_ STKDR 161_ KLLLT 166_ AQQML 171_ QDSKT 176_ KIDII 181_ RMQLR 186_ RALQA 191_ GQLEN 196_ QAAPD 201_ DTQGS 206_ PDLGA 211_ VELRI 216_ EELRH 221_ HFRVE 226_ HAVAE 231_ GAKNV 236_ LRLLS 241_ AAKAP 246_ DRKAV 251_ SEAQE 256_ KLTES 261_ NQKLG 266_ LLREA 271_ LERRL 276_ GELPA 281_ DHPKG 286_ RLLRE 291_ ELAAA 296_ SSAAF 301_ STRLA 306_ GPFPA 311_ THYST 316_ LCKPA 321_ PLTGT 326_ LEVRV 331_ VGCRD 336_ LPETI 341_ PWNPT 346_ PSMGG 351_ PGTPD 356_ SRPPF 361_ LSRPA 366_ RGLYS 371_ RSGSL 376_ SGRSS 381_ LKAEA 386_ ENTSE 391_ VSTVL 396_ KLDNT 401_ VVGQT 406_ SWKPC 411_ GPNAW 416_ DQSFT 421_ LELER 426_ ARELE 431_ LAVFW 436_ RDQRG 441_ LCALK 446_ FLKLE 451_ DFLDN 456_ ERHEV 461_ QLDME 466_ PQGCL 471_ VAEVT 476_ FRNPV 481_ IERIP 486_ RLRRQ 491_ KKIFS 496_ KQQGK 501_ AFQRA 506_ RQMNI 511_ DVATW 516_ VRLLR 521_ RLIPN 526_ ATGTG 531_ TFSPG 536_ ASPGS 541_ EARTT 546_ GDISV 551_ EKLNL 556_ GTDSD 561_ SSPQK 566_ SSRDP 571_ PSSPS 576_ SLSSP 581_ IQEST 586_ APELP 591_ SETQE 596_ TPGPA 601_ LCSPL 606_ RKSPL 611_ TLEDF 616_ KFLAV 621_ LGRGH 626_ FGKVL 631_ LSEFR 636_ PSGEL 641_ FAIKA 646_ LKKGD 651_ IVARD 656_ EVESL 661_ MCEKR 666_ ILAAV 671_ TSAGH 676_ PFLVN 681_ LFGCF 686_ QTPEH 691_ VCFVM 696_ EYSAG 701_ GDLML 706_ HIHSD 711_ VFSEP 716_ RAIFY 721_ SACVV 726_ LGLQF 731_ LHEHK 736_ IVYRD 741_ LKLDN 746_ LLLDT 751_ EGYVK 756_ IADFG 761_ LCKEG 766_ MGYGD 771_ RTSTF 776_ CGTPE 781_ FLAPE 786_ VLTDT 791_ SYTRA 796_ VDWWG 801_ LGVLL 806_ YEMLV 811_ GESPF 816_ PGDDE 821_ EEVFD 826_ SIVND 831_ EVRYP 836_ RFLSA 841_ EAIGI 846_ MRRLL 851_ RRNPE 856_ RRLGS 861_ SERDA 866_ EDVKK 871_ QPFFR 876_ TLGWE 881_ ALLAR 886_ RLPPP 891_ FVPTL 896_ SGRTD 901_ VSNFD 906_ EEFTG 911_ EAPTL 916_ SPPRD 921_ ARPLT 926_ AAEQA 931_ AFLDF 936_DFVAG
1: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro