Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
1_MASNP 6_ ERGEI 11_ LLTEL 16_ QGDSR 21_ SLPFS 26_ ENVSA 31_ VQKLD 36_ FSDTM 41_ VQQKL 46_ DDIKD 51_ RIKRE 56_ IRKEL 61_ KIKEG 66_ AENLR 71_ KVTTD 76_ KKSLA 81_ YVDNI 86_ LKKSN 91_ KKLEE 96_ LHHKL 101_ QELNA 106_ HIVVS 111_ DPEDI 116_ TDCPR 121_ TPDTP 126_ NNDPR 131_ CSTSN 136_ NRLKA 141_ LQKQL 146_ DIELK 151_ VKQGA 156_ ENMIQ 161_ MYSNG 166_ SSKDR 171_ KLHGT 176_ AQQLL 181_ QDSKT 186_ KIEVI 191_ RMQIL 196_ QAVQT 201_ NELAF 206_ DNAKP 211_ VISPL 216_ ELRME 221_ ELRHH 226_ FRIEF 231_ AVAEG 236_ AKNVM 241_ KLLGS 246_ GKVTD 251_ RKALS 256_ EAQAR 261_ FNESS 266_ QKLDL 271_ LKYSL 276_ EQRLN 281_ EVPKN 286_ HPKSR 291_ IIIEE 296_ LSLVA 301_ ASPTL 306_ SPRQS 311_ MISTQ 316_ NQYST 321_ LSKPA 326_ ALTGT 331_ LEVRL 336_ MGCQD 341_ ILENV 346_ PGRSK 351_ ATSVA 356_ LPGWS 361_ PSETR 366_ SSFMS 371_ RTSKS 376_ KSGSS 381_ RNLLK 386_ TDDLS 391_ NDVCA 396_ VLKLD 401_ NTVVG 406_ QTSWK 411_ PISNQ 416_ SWDQK 421_ FTLEL 426_ DRSRE 431_ LEISV 436_ YWRDW 441_ RSLCA 446_ VKFLR 451_ LEDFL 456_ DNQRH 461_ GMCLY 466_ LEPQG 471_ TLFAE 476_ VTFFN 481_ PVIER 486_ RPKLQ 491_ RQKKI 496_ FSKQQ 501_ GKTFL 506_ RAPQM 511_ NINIA 516_ TWGRL 521_ VRRAI 526_ PTVNH 531_ SGTFS 536_ PQAPV 541_ PTTVP 546_ VVDVR 551_ IPQLA 556_ PPASD 561_ STVTK 566_ LDFDL 571_ EPEPP 576_ PAPPR 581_ ASSLG 586_ EIDES 591_ SELRV 596_ LDIPG 601_ QDSET 606_ VFDIQ 611_ NDRNS 616_ ILPKS 621_ QSEYK 626_ PDTPQ 631_ SGLEY 636_ SGIQE 641_ LEDRR 646_ SQQRF 651_ QFNLQ 656_ DFRCC 661_ AVLGR 666_ GHFGK 671_ VLLAE 676_ YKNTN 681_ EMFAI 686_ KALKK 691_ GDIVA 696_ RDEVD 701_ SLMCE 706_ KRIFE 711_ TVNSV 716_ RHPFL 721_ VNLFA 726_ CFQTK 731_ EHVCF 736_ VMEYA 741_ AGGDL 746_ MMHIH 751_ TDVFS 756_ EPRAV 761_ FYAAC 766_ VVLGL 771_ QYLHE 776_ HKIVY 781_ RDLKL 786_ DNLLL 791_ DTEGF 796_ VKIAD 801_ FGLCK 806_ EGMGY 811_ GDRTS 816_ TFCGT 821_ PEFLA 826_ PEVLT 831_ ETSYT 836_ RAVDW 841_ WGLGV 846_ LIYEM 851_ LVGES 856_ PFPGD 861_ DEEEV 866_ FDSIV 871_ NDEVR 876_ YPRFL 881_ STEAI 886_ SIMRR 891_ LLRRN 896_ PERRL 901_ GASEK 906_ DAEDV 911_ KKHPF 916_ FRLID 921_ WSALM 926_ DKKVK 931_ PPFIP 936_ TIRGR 941_ EDVSN 946_ FDDEF 951_ TSEAP 956_ ILTPP 961_ REPRI 966_ LSEEE 971_ QEMFR 976_DFDYI
1: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747)
2: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication