Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15)
1_MNQFG 6_ PSALI 11_ NLSNF 16_ SSIKP 21_ EPAST 26_ PPQGS 31_ MANST 36_ AVVKI 41_ PGTPG 46_ AGGRL 51_ SPENN 56_ QVLTK 61_ KKLQD 66_ LVREV 71_ DPNEQ 76_ LDEDV 81_ EEMLL 86_ QIADD 91_ FIESV 96_ VTAAC 101_ QLARH 106_ RKSST 111_ LEVKD 116_ VQLHL 121_ ERQWN 126_ MWIPG 131_ FGSEE 136_ IRPYK 141_ KACTT 146_ EAHKQ 151_ RMALI 156_RKTTK
1: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:7729427, PubMed:8598932, PubMed:8663456, PubMed:9674425, PubMed:9885574)