Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Lutein isomerase) (Meso-zeaxanthin isomerase) (EC 5.3.3.22) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase)
1_MSIQV 6_ EHPAG 11_ GYKKL 16_ FETVE 21_ ELSSP 26_ LTAHV 31_ TGRIP 36_ LWLTG 41_ SLLRC 46_ GPGLF 51_ EVGSE 56_ PFYHL 61_ FDGQA 66_ LLHKF 71_ DFKEG 76_ HVTYH 81_ RRFIR 86_ TDAYV 91_ RAMTE 96_ KRIVI 101_ TEFGT 106_ CAFPD 111_ PCKNI 116_ FSRFF 121_ SYFRG 126_ VEVTD 131_ NALVN 136_ VYPVG 141_ EDYYA 146_ CTETN 151_ FITKI 156_ NPETL 161_ ETIKQ 166_ VDLCN 171_ YVSVN 176_ GATAH 181_ PHIEN 186_ DGTVY 191_ NIGNC 196_ FGKNF 201_ SIAYN 206_ IVKIP 211_ PLQAD 216_ KEDPI 221_ SKSEI 226_ VVQFP 231_ CSDRF 236_ KPSYV 241_ HSFGL 246_ TPNYI 251_ VFVET 256_ PVKIN 261_ LFKFL 266_ SSWSL 271_ WGANY 276_ MDCFE 281_ SNETM 286_ GVWLH 291_ IADKK 296_ RKKYL 301_ NNKYR 306_ TSPFN 311_ LFHHI 316_ NTYED 321_ NGFLI 326_ VDLCC 331_ WKGFE 336_ FVYNY 341_ LYLAN 346_ LRENW 351_ EEVKK 356_ NARKA 361_ PQPEV 366_ RRYVL 371_ PLNID 376_ KADTG 381_ KNLVT 386_ LPNTT 391_ ATAIL 396_ CSDET 401_ IWLEP 406_ EVLFS 411_ GPRQA 416_ FEFPQ 421_ INYQK 426_ YCGKP 431_ YTYAY 436_ GLGLN 441_ HFVPD 446_ RLCKL 451_ NVKTK 456_ ETWVW 461_ QEPDS 466_ YPSEP 471_ IFVSH 476_ PDALE 481_ EDDGV 486_ VLSVV 491_ VSPGA 496_ GQKPA 501_ YLLIL 506_ NAKDL 511_ SEVAR 516_ AEVEI 521_ NIPVT 526_FHGLF
1: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity)