Gene name: CDC37

Uniprot entry:

Q16543

Protein names:

Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]

Protein sequence:

1_MVDYS 6_ VWDHI 11_ EVSDD 16_ EDETH 21_ PNIDT 26_ ASLFR 31_ WRHQA 36_ RVERM 41_ EQFQK 46_ EKEEL 51_ DRGCR 56_ ECKRK 61_ VAECQ 66_ RKLKE 71_ LEVAE 76_ GGKAE 81_ LERLQ 86_ AEAQQ 91_ LRKEE 96_ RSWEQ 101_ KLEEM 106_ RKKEK 111_ SMPWN 116_ VDTLS 121_ KDGFS 126_ KSMVN 131_ TKPEK 136_ TEEDS 141_ EEVRE 146_ QKHKT 151_ FVEKY 156_ EKQIK 161_ HFGML 166_ RRWDD 171_ SQKYL 176_ SDNVH 181_ LVCEE 186_ TANYL 191_ VIWCI 196_ DLEVE 201_ EKCAL 206_ MEQVA 211_ HQTIV 216_ MQFIL 221_ ELAKS 226_ LKVDP 231_ RACFR 236_ QFFTK 241_ IKTAD 246_ RQYME 251_ GFNDE 256_ LEAFK 261_ ERVRG 266_ RAKLR 271_ IEKAM 276_ KEYEE 281_ EERKK 286_ RLGPG 291_ GLDPV 296_ EVYES 301_ LPEEL 306_ QKCFD 311_ VKDVQ 316_ MLQDA 321_ ISKMD 326_ PTDAK 331_ YHMQR 336_ CIDSG 341_ LWVPN 346_ SKASE 351_ AKEGE 356_ EAGPG 361_ DPLLE 366_ AVPKT 371_GDEKD

Protein annotations

Protein functions:

1: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206)