Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7)
1_MPKGR 6_ QKVPH 11_ LDAPL 16_ GLPTC 21_ LWLEL 26_ AGLFL 31_ LVPWV 36_ MGLAG 41_ TGGPD 46_ GQGTG 51_ GPSWA 56_ VHLES 61_ LEGDG 66_ EEETL 71_ EQQAD 76_ ALAQA 81_ AGLVN 86_ AGRIG 91_ ELQGH 96_ YLFVQ 101_ PAGHR 106_ PALEV 111_ EAIRQ 116_ QVEAV 121_ LAGHE 126_ AVRWH 131_ SEQRL 136_ LRRAK 141_ RSVHF 146_ NDPKY 151_ PQQWH 156_ LNNRR 161_ SPGRD 166_ INVTG 171_ VWERN 176_ VTGRG 181_ VTVVV 186_ VDDGV 191_ EHTIQ 196_ DIAPN 201_ YSPEG 206_ SYDLN 211_ SNDPD 216_ PMPHP 221_ DVENG 226_ NHHGT 231_ RCAGE 236_ IAAVP 241_ NNSFC 246_ AVGVA 251_ YGSRI 256_ AGIRV 261_ LDGPL 266_ TDSME 271_ AVAFN 276_ KHYQI 281_ NDIYS 286_ CSWGP 291_ DDDGK 296_ TVDGP 301_ HQLGK 306_ AALQH 311_ GVIAG 316_ RQGFG 321_ SIFVV 326_ ASGNG 331_ GQHND 336_ NCNYD 341_ GYANS 346_ IYTVT 351_ IGAVD 356_ EEGRM 361_ PFYAE 366_ ECASM 371_ LAVTF 376_ SGGDK 381_ MLRSI 386_ VTTDW 391_ DLQKG 396_ TGCTE 401_ GHTGT 406_ SAAAP 411_ LAAGM 416_ IALML 421_ QVRPC 426_ LTWRD 431_ VQHII 436_ VFTAT 441_ RYEDR 446_ RAEWV 451_ TNEAG 456_ FSHSH 461_ QHGFG 466_ LLNAW 471_ RLVNA 476_ AKIWT 481_ SVPYL 486_ ASYVS 491_ PVLKE 496_ NKAIP 501_ QSPRS 506_ LEVLW 511_ NVSRM 516_ DLEMS 521_ GLKTL 526_ EHVAV 531_ TVSIT 536_ HPRRG 541_ SLELK 546_ LFCPS 551_ GMMSL 556_ IGAPR 561_ SMDSD 566_ PNGFN 571_ DWTFS 576_ TVRCW 581_ GERAR 586_ GTYRL 591_ VIRDV 596_ GDESF 601_ QVGIL 606_ RQWQL 611_ TLYGS 616_ VWSAV 621_ DIRDR 626_ QRLLE 631_ SAMSG 636_ KYLHD 641_ DFALP 646_ CPPGL 651_ KIPEE 656_ DGYTI 661_ TPNTL 666_ KTLVL 671_ VGCFT 676_ VFWTV 681_ YYMLE 686_ VYLSQ 691_ RNVAS 696_ NQVCR 701_ SGPCH 706_ WPHRS 711_ RKAKE 716_ EGTEL 721_ ESVPL 726_ CSSKD 731_ PDEVE 736_ TESRG 741_ PPTTS 746_ DLLAP 751_ DLLEQ 756_ GDWSL 761_ SQNKS 766_ ALDCP 771_ HQHLD 776_VPHGK
1: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway