Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR)
1_MLKVT 6_ VPSCS 11_ ASSCS 16_ SVTAS 21_ AAPGT 26_ ASLVP 31_ DYWID 36_ GSNRD 41_ ALSDF 46_ FEVES 51_ ELGRG 56_ ATSIV 61_ YRCKQ 66_ KGTQK 71_ PYALK 76_ VLKKT 81_ VDKKI 86_ VRTEI 91_ GVLLR 96_ LSHPN 101_ IIKLK 106_ EIFET 111_ PTEIS 116_ LVLEL 121_ VTGGE 126_ LFDRI 131_ VEKGY 136_ YSERD 141_ AADAV 146_ KQILE 151_ AVAYL 156_ HENGI 161_ VHRDL 166_ KPENL 171_ LYATP 176_ APDAP 181_ LKIAD 186_ FGLSK 191_ IVEHQ 196_ VLMKT 201_ VCGTP 206_ GYCAP 211_ EILRG 216_ CAYGP 221_ EVDMW 226_ SVGII 231_ TYILL 236_ CGFEP 241_ FYDER 246_ GDQFM 251_ FRRIL 256_ NCEYY 261_ FISPW 266_ WDEVS 271_ LNAKD 276_ LVRKL 281_ IVLDP 286_ KKRLT 291_ TFQAL 296_ QHPWV 301_ TGKAA 306_ NFVHM 311_ DTAQK 316_ KLQEF 321_ NARRK 326_ LKAAV 331_ KAVVA 336_ SSRLG 341_ SASSS 346_ HGSIQ 351_ ESHKA 356_ SRDPS 361_ PIQDG 366_ NEDMK 371_ AIPEG 376_ EKIQG 381_ DGAQA 386_ AVKGA 391_ QAELM 396_ KVQAL 401_ EKVKG 406_ ADINA 411_ EEAPK 416_ MVPKA 421_ VEDGI 426_ KVADL 431_ ELEEG 436_ LAEEK 441_ LKTVE 446_ EAAAP 451_ REGQG 456_ SSAVG 461_ FEVPQ 466_QDVIL
1: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18