Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234)
1_MGNCL 6_ HRAEL 11_ SPSTE 16_ NSSQL 21_ DFEDV 26_ WNSSY 31_ GVNDS 36_ FPDGD 41_ YGANL 46_ EAAAP 51_ CHSCN 56_ LLDDS 61_ ALPFF 66_ ILTSV 71_ LGILA 76_ SSTVL 81_ FMLFR 86_ PLFRW 91_ QLCPG 96_ WPVLA 101_ QLAVG 106_ SALFS 111_ IVVPV 116_ LAPGL 121_ GSTRS 126_ SALCS 131_ LGYCV 136_ WYGSA 141_ FAQAL 146_ LLGCH 151_ ASLGH 156_ RLGAG 161_ QVPGL 166_ TLGLT 171_ VGIWG 176_ VAALL 181_ TLPVT 186_ LASGA 191_ SGGLC 196_ TLIYS 201_ TELKA 206_ LQATH 211_ TVACL 216_ AIFVL 221_ LPLGL 226_ FGAKG 231_ LKKAL 236_ GMGPG 241_ PWMNI 246_ LWAWF 251_ IFWWP 256_ HGVVL 261_ GLDFL 266_ VRSKL 271_ LLLST 276_ CLAQQ 281_ ALDLL 286_ LNLAE 291_ ALAIL 296_ HCVAT 301_ PLLLA 306_ LFCHQ 311_ ATRTL 316_ LPSLP 321_ LPEGW 326_ SSHLD 331_TLGSK
1: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels
2: (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium vivax
3: (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi