Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
1_MASKE 6_ MFEDT 11_ VEERV 16_ INEEY 21_ KIWKK 26_ NTPFL 31_ YDLVM 36_ THALQ 41_ WPSLT 46_ VQWLP 51_ EVTKP 56_ EGKDY 61_ ALHWL 66_ VLGTH 71_ TSDEQ 76_ NHLVV 81_ ARVHI 86_ PNDDA 91_ QFDAS 96_ HCDSD 101_ KGEFG 106_ GFGSV 111_ TGKIE 116_ CEIKI 121_ NHEGE 126_ VNRAR 131_ YMPQN 136_ PHIIA 141_ TKTPS 146_ SDVLV 151_ FDYTK 156_ HPAKP 161_ DPSGE 166_ CNPDL 171_ RLRGH 176_ QKEGY 181_ GLSWN 186_ SNLSG 191_ HLLSA 196_ SDDHT 201_ VCLWD 206_ INAGP 211_ KEGKI 216_ VDAKA 221_ IFTGH 226_ SAVVE 231_ DVAWH 236_ LLHES 241_ LFGSV 246_ ADDQK 251_ LMIWD 256_ TRSNT 261_ TSKPS 266_ HLVDA 271_ HTAEV 276_ NCLSF 281_ NPYSE 286_ FILAT 291_ GSADK 296_ TVALW 301_ DLRNL 306_ KLKLH 311_ TFESH 316_ KDEIF 321_ QVHWS 326_ PHNET 331_ ILASS 336_ GTDRR 341_ LNVWD 346_ LSKIG 351_ EEQSA 356_ EDAED 361_ GPPEL 366_ LFIHG 371_ GHTAK 376_ ISDFS 381_ WNPNE 386_ PWVIC 391_ SVSED 396_ NIMQI 401_ WQMAE 406_ NIYND 411_ EESDV 416_TTSEL
1: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex