Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)
1_MEPLK 6_ SLFLK 11_ SPLGS 16_ WNGSG 21_ SGGGG 26_ GGGGG 31_ RPEGS 36_ PKAAG 41_ YANPV 46_ WTALF 51_ DYEPS 56_ GQDEL 61_ ALRKG 66_ DRVEV 71_ LSRDA 76_ AISGD 81_ EGWWA 86_ GQVGG 91_ QVGIF 96_ PSNYV 101_ SRGGG 106_ PPPCE 111_ VASFQ 116_ ELRLE 121_ EVIGI 126_ GGFGK 131_ VYRGS 136_ WRGEL 141_ VAVKA 146_ ARQDP 151_ DEDIS 156_ VTAES 161_ VRQEA 166_ RLFAM 171_ LAHPN 176_ IIALK 181_ AVCLE 186_ EPNLC 191_ LVMEY 196_ AAGGP 201_ LSRAL 206_ AGRRV 211_ PPHVL 216_ VNWAV 221_ QIARG 226_ MHYLH 231_ CEALV 236_ PVIHR 241_ DLKSN 246_ NILLL 251_ QPIES 256_ DDMEH 261_ KTLKI 266_ TDFGL 271_ AREWH 276_ KTTQM 281_ SAAGT 286_ YAWMA 291_ PEVIK 296_ ASTFS 301_ KGSDV 306_ WSFGV 311_ LLWEL 316_ LTGEV 321_ PYRGI 326_ DCLAV 331_ AYGVA 336_ VNKLT 341_ LPIPS 346_ TCPEP 351_ FAQLM 356_ ADCWA 361_ QDPHR 366_ RPDFA 371_ SILQQ 376_ LEALE 381_ AQVLR 386_ EMPRD 391_ SFHSM 396_ QEGWK 401_ REIQG 406_ LFDEL 411_ RAKEK 416_ ELLSR 421_ EEELT 426_ RAARE 431_ QRSQA 436_ EQLRR 441_ REHLL 446_ AQWEL 451_ EVFER 456_ ELTLL 461_ LQQVD 466_ RERPH 471_ VRRRR 476_ GTFKR 481_ SKLRA 486_ RDGGE 491_ RISMP 496_ LDFKH 501_ RITVQ 506_ ASPGL 511_ DRRRN 516_ VFEVG 521_ PGDSP 526_ TFPRF 531_ RAIQL 536_ EPAEP 541_ GQAWG 546_ RQSPR 551_ RLEDS 556_ SNGER 561_ RACWA 566_ WGPSS 571_ PKPGE 576_ AQNGR 581_ RRSRM 586_ DEATW 591_ YLDSD 596_ DSSPL 601_ GSPST 606_ PPALN 611_ GNPPR 616_ PSLEP 621_ EEPKR 626_ PVPAE 631_ RGSSS 636_ GTPKL 641_ IQRAL 646_ LRGTA 651_ LLASL 656_ GLGRD 661_ LQPPG 666_ GPGRE 671_ RGESP 676_ TTPPT 681_ PTPAP 686_ CPTEP 691_ PPSPL 696_ ICFSL 701_ KTPDS 706_ PPTPA 711_ PLLLD 716_ LGIPV 721_ GQRSA 726_ KSPRR 731_ EEEPR 736_ GGTVS 741_ PPPGT 746_ SRSAP 751_ GTPGT 756_ PRSPP 761_ LGLIS 766_ RPRPS 771_ PLRSR 776_ IDPWS 781_ FVSAG 786_ PRPSP 791_ LPSPQ 796_ PAPRR 801_ APWTL 806_ FPDSD 811_ PFWDS 816_ PPANP 821_ FQGGP 826_ QDCRA 831_ QTKDM 836_ GAQAP 841_WVPEA
1: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle