Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
1_MEKKC 6_ TLYFL 11_ VLLPF 16_ FMILV 21_ TAELE 26_ ESPED 31_ SIQLG 36_ VTRNK 41_ IMTAQ 46_ YECYQ 51_ KIMQD 56_ PIQQA 61_ EGVYC 66_ NRTWD 71_ GWLCW 76_ NDVAA 81_ GTESM 86_ QLCPD 91_ YFQDF 96_ DPSEK 101_ VTKIC 106_ DQDGN 111_ WFRHP 116_ ASNRT 121_ WTNYT 126_ QCNVN 131_ THEKV 136_ KTALN 141_ LFYLT 146_ IIGHG 151_ LSIAS 156_ LLISL 161_ GIFFY 166_ FKSLS 171_ CQRIT 176_ LHKNL 181_ FFSFV 186_ CNSVV 191_ TIIHL 196_ TAVAN 201_ NQALV 206_ ATNPV 211_ SCKVS 216_ QFIHL 221_ YLMGC 226_ NYFWM 231_ LCEGI 236_ YLHTL 241_ IVVAV 246_ FAEKQ 251_ HLMWY 256_ YFLGW 261_ GFPLI 266_ PACIH 271_ AIARS 276_ LYYND 281_ NCWIS 286_ SDTHL 291_ LYIIH 296_ GPICA 301_ ALLVN 306_ LFFLL 311_ NIVRV 316_ LITKL 321_ KVTHQ 326_ AESNL 331_ YMKAV 336_ RATLI 341_ LVPLL 346_ GIEFV 351_ LIPWR 356_ PEGKI 361_ AEEVY 366_ DYIMH 371_ ILMHF 376_ QGLLV 381_ STIFC 386_ FFNGE 391_ VQAIL 396_ RRNWN 401_ QYKIQ 406_ FGNSF 411_ SNSEA 416_ LRSAS 421_ YTVST 426_ ISDGP 431_ GYSHD 436_ CPSEH 441_ LNGKS 446_ IHDIE 451_ NVLLK 456_PENLY
1: G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:32296767, PubMed:9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32296767, PubMed:8626685)