Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)
1_MASGQ 6_ GPGPP 11_ RQECG 16_ EPALP 21_ SASEE 26_ QVAQD 31_ TEEVF 36_ RSYVF 41_ YRHQQ 46_ EQEAE 51_ GVAAP 56_ ADPEM 61_ VTLPL 66_ QPSST 71_ MGQVG 76_ RQLAI 81_ IGDDI 86_ NRRYD 91_ SEFQT 96_ MLQHL 101_ QPTAE 106_ NAYEY 111_ FTKIA 116_ TSLFE 121_ SGINW 126_ GRVVA 131_ LLGFG 136_ YRLAL 141_ HVYQH 146_ GLTGF 151_ LGQVT 156_ RFVVD 161_ FMLHH 166_ CIARW 171_ IAQRG 176_ GWVAA 181_ LNLGN 186_ GPILN 191_ VLVVL 196_ GVVLL 201_ GQFVV 206_RRFFK
1: Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases