Protein NKG7 (G-CSF-induced gene 1 protein) (GIG-1 protein) (Granule membrane protein of 17 kDa) (GMP-17) (Natural killer cell protein 7) (p15-TIA-1)
1_MELCR 6_ SLALL 11_ GGSLG 16_ LMFCL 21_ IALST 26_ DFWFE 31_ AVGPT 36_ HSAHS 41_ GLWPT 46_ GHGDI 51_ ISGYI 56_ HVTQT 61_ FSIMA 66_ VLWAL 71_ VSVSF 76_ LVLSC 81_ FPSLF 86_ PPGHG 91_ PLVST 96_ TAAFA 101_ AAISM 106_ VVAMA 111_ VYTSE 116_ RWDQP 121_ PHPQI 126_ QTFFS 131_ WSFYL 136_ GWVSA 141_ ILLLC 146_ TGALS 151_ LGAHC 156_GGPRP
1: Regulates cytotoxic granule exocytosis in effector lymphocytes, thus acting as a critical mediator of inflammation in a broad range of infectious and non-infectious diseases (By similarity). Essential for cytotoxic degranulation of natural killer (NK) cells and CD8(+) T-cells and for the activation of CD4(+) T-cells following infection (By similarity). Plays a critical role in CD8(+) T-cell and NK cell-mediated cytolysis of target cells and contributes to the cytolytic activity via the perforin/granzyme pathway by enhancing exocytosis of LAMP1-carrying lytic granules (By similarity). Contributes to NK cell-mediated control of cancer metastasis (By similarity)