Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2) (Nuclear factor, erythroid-derived 2 45 kDa subunit) (p45 NF-E2)
1_MSPCP 6_ PQQSR 11_ NRVIQ 16_ LSTSE 21_ LGEME 26_ LTWQE 31_ IMSIT 36_ ELQGL 41_ NAPSE 46_ PSFEP 51_ QAPAP 56_ YLGPP 61_ PPTTY 66_ CPCSI 71_ HPDSG 76_ FPLPP 81_ PPYEL 86_ PASTS 91_ HVPDP 96_ PYSYG 101_ NMAIP 106_ VSKPL 111_ SLSGL 116_ LSEPL 121_ QDPLA 126_ LLDIG 131_ LPAGP 136_ PKPQE 141_ DPESD 146_ SGLSL 151_ NYSDA 156_ ESLEL 161_ EGTEA 166_ GRRRS 171_ EYVEM 176_ YPVEY 181_ PYSLM 186_ PNSLA 191_ HSNYT 196_ LPAAE 201_ TPLAL 206_ EPSSG 211_ PVRAK 216_ PTARG 221_ EAGSR 226_ DERRA 231_ LAMKI 236_ PFPTD 241_ KIVNL 246_ PVDDF 251_ NELLA 256_ RYPLT 261_ ESQLA 266_ LVRDI 271_ RRRGK 276_ NKVAA 281_ QNCRK 286_ RKLET 291_ IVQLE 296_ RELER 301_ LTNER 306_ ERLLR 311_ ARGEA 316_ DRTLE 321_ VMRQQ 326_ LTELY 331_ RDIFQ 336_ HLRDE 341_ SGNSY 346_ SPEEY 351_ ALQQA 356_ ADGTI 361_ FLVPR 366_GTKME
1: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron