Syntaxin-1A (Neuron-specific antigen HPC-1)
1_MKDRT 6_ QELRT 11_ AKDSD 16_ DDDDV 21_ AVTVD 26_ RDRFM 31_ DEFFE 36_ QVEEI 41_ RGFID 46_ KIAEN 51_ VEEVK 56_ RKHSA 61_ ILASP 66_ NPDEK 71_ TKEEL 76_ EELMS 81_ DIKKT 86_ ANKVR 91_ SKLKS 96_ IEQSI 101_ EQEEG 106_ LNRSS 111_ ADLRI 116_ RKTQH 121_ STLSR 126_ KFVEV 131_ MSEYN 136_ ATQSD 141_ YRERC 146_ KGRIQ 151_ RQLEI 156_ TGRTT 161_ TSEEL 166_ EDMLE 171_ SGNPA 176_ IFASG 181_ IIMDS 186_ SISKQ 191_ ALSEI 196_ ETRHS 201_ EIIKL 206_ ENSIR 211_ ELHDM 216_ FMDMA 221_ MLVES 226_ QGEMI 231_ DRIEY 236_ NVEHA 241_ VDYVE 246_ RAVSD 251_ TKKAV 256_ KYQSK 261_ ARRKK 266_ IMIII 271_ CCVIL 276_ GIVIA 281_STVGG
1: Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity)