C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)]
1_MKISV 6_ AAIPF 11_ FLLIT 16_ IALGT 21_ KTESS 26_ SRGPY 31_ HPSEC 36_ CFTYT 41_ TYKIP 46_ RQRIM 51_ DYYET 56_ NSQCS 61_ KPGIV 66_ FITKR 71_ GHSVC 76_ TNPSD 81_ KWVQD 86_YIKDM
1: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5