Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
1_MADGV 6_ DHIDI 11_ YADVG 16_ EEFNQ 21_ EAEYG 26_ GHDQI 31_ DLYDD 36_ VISPS 41_ ANNGD 46_ APEDR 51_ DYMDT 56_ LPPTV 61_ GDDVG 66_ KGAAP 71_ NVVYT 76_ YTGKR 81_ IALYI 86_ GNLTW 91_ WTTDE 96_ DLTEA 101_ VHSLG 106_ VNDIL 111_ EIKFF 116_ ENRAN 121_ GQSKG 126_ FALVG 131_ VGSEA 136_ SSKKL 141_ MDLLP 146_ KRELH 151_ GQNPV 156_ VTPCN 161_ KQFLS 166_ QFEMQ 171_ SRKTT 176_ QSGQM 181_ SGEGK 186_ AGPPG 191_ GSSRA 196_ AFPQG 201_ GRGRG 206_ RFPGA 211_ VPGGD 216_ RFPGP 221_ AGPGG 226_ PPPPF 231_ PAGQT 236_ PPRPP 241_ LGPPG 246_ PPGPP 251_ GPPPP 256_ GQVLP 261_ PPLAG 266_ PPNRG 271_ DRPPP 276_ PVLFP 281_ GQPFG 286_ QPPLG 291_ PLPPG 296_ PPPPV 301_ PGYGP 306_ PPGPP 311_ PPQQG 316_ PPPPP 321_ GPFPP 326_ RPPGP 331_ LGPPL 336_ TLAPP 341_ PHLPG 346_ PPPGA 351_ PPPAP 356_ HVNPA 361_ FFPPP 366_ TNSGM 371_ PTSDS 376_ RGPPP 381_ TDPYG 386_ RPPPY 391_ DRGDY 396_ GPPGR 401_ EMDTA 406_ RTPLS 411_ EAEFE 416_ EIMNR 421_ NRAIS 426_ SSAIS 431_ RAVSD 436_ ASAGD 441_ YGSAI 446_ ETLVT 451_ AISLI 456_ KQSKV 461_ SADDR 466_ CKVLI 471_ SSLQD 476_ CLHGI 481_ ESKSY 486_ GSGSR 491_ RERSR 496_ ERDHS 501_ RSREK 506_ SRRHK 511_ SRSRD 516_ RHDDY 521_ YRERS 526_ RERER 531_ HRDRD 536_ RDRDR 541_ ERDRE 546_REYRH
1: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, PubMed:8626397, PubMed:9659921). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:14690600, PubMed:8626397, PubMed:9659921). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:21295486, PubMed:29276085). Plays a role in mRNA export (PubMed:19864460)
2: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro)