Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase)
1_MAWAA 6_ LLGLL 11_ AALLL 16_ LLLLS 21_ RRRTR 26_ RPGEP 31_ PLDLG 36_ SIPWL 41_ GYALD 46_ FGKDA 51_ ASFLT 56_ RMKEK 61_ HGDIF 66_ TILVG 71_ GRYVT 76_ VLLDP 81_ HSYDA 86_ VVWEP 91_ RTRLD 96_ FHAYA 101_ IFLME 106_ RIFDV 111_ QLPHY 116_ SPSDE 121_ KARMK 126_ LTLLH 131_ RELQA 136_ LTEAM 141_ YTNLH 146_ AVLLG 151_ DATEA 156_ GSGWH 161_ EMGLL 166_ DFSYS 171_ FLLRA 176_ GYLTL 181_ YGIEA 186_ LPRTH 191_ ESQAQ 196_ DRVHS 201_ ADVFH 206_ TFRQL 211_ DRLLP 216_ KLARG 221_ SLSVG 226_ DKDHM 231_ CSVKS 236_ RLWKL 241_ LSPAR 246_ LARRA 251_ HRSKW 256_ LESYL 261_ LHLEE 266_ MGVSE 271_ EMQAR 276_ ALVLQ 281_ LWATQ 286_ GNMGP 291_ AAFWL 296_ LLFLL 301_ KNPEA 306_ LAAVR 311_ GELES 316_ ILWQA 321_ EQPVS 326_ QTTTL 331_ PQKVL 336_ DSTPV 341_ LDSVL 346_ SESLR 351_ LTAAP 356_ FITRE 361_ VVVDL 366_ AMPMA 371_ DGREF 376_ NLRRG 381_ DRLLL 386_ FPFLS 391_ PQRDP 396_ EIYTD 401_ PEVFK 406_ YNRFL 411_ NPDGS 416_ EKKDF 421_ YKDGK 426_ RLKNY 431_ NMPWG 436_ AGHNH 441_ CLGRS 446_ YAVNS 451_ IKQFV 456_ FLVLV 461_ HLDLE 466_ LINAD 471_ VEIPE 476_ FDLSR 481_ YGFGL 486_ MQPEH 491_DVPVR
1: Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323)