Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A)
1_MQLRK 6_ MQTVK 11_ KEQAS 16_ LDASS 21_ NVDKM 26_ MVLNS 31_ ALTEV 36_ SEDST 41_ TGEEL 46_ LLSEG 51_ SVGKN 56_ KSSAC 61_ RRKRE 66_ FIPDE 71_ KKDAM 76_ YWEKR 81_ RKNNE 86_ AAKRS 91_ REKRR 96_ LNDLV 101_ LENKL 106_ IALGE 111_ ENATL 116_ KAELL 121_ SLKLK 126_ FGLIS 131_ STAYA 136_ QEIQK 141_ LSNST 146_ AVYFQ 151_ DYQTS 156_ KSNVS 161_ SFVDE 166_ HEPSM 171_ VSSSC 176_ ISVIK 181_ HSPQS 186_ SLSDV 191_ SEVSS 196_ VEHTQ 201_ ESSVQ 206_ GSCRS 211_ PENKF 216_ QIIKQ 221_ EPMEL 226_ ESYTR 231_ EPRDD 236_ RGSYT 241_ ASIYQ 246_ NYMGN 251_ SFSGY 256_ SHSPP 261_ LLQVN 266_ RSSSN 271_ SPRTS 276_ ETDDG 281_ VVGKS 286_ SDGED 291_ EQQVP 296_ KGPIH 301_ SPVEL 306_ KHVHA 311_ TVVKV 316_ PEVNS 321_ SALPH 326_ KLRIK 331_ AKAMQ 336_ IKVEA 341_ FDNEF 346_ EATQK 351_ LSSPI 356_ DMTSK 361_ RHFEL 366_ EKHSA 371_ PSMVH 376_ SSLTP 381_ FSVQV 386_ TNIQD 391_ WSLKS 396_ EHWHQ 401_ KELSG 406_ KTQNS 411_ FKTGV 416_ VEMKD 421_ SGYKV 426_ SDPEN 431_ LYLKQ 436_ GIANL 441_ SAEVV 446_ SLKRL 451_ IATQP 456_ISASD
1: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity)