Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain]
1_MAQKG 6_ VLGPG 11_ QLGAV 16_ AILLY 21_ LGLLR 26_ SGTGA 31_ EGAEA 36_ PCGVA 41_ PQARI 46_ TGGSS 51_ AVAGQ 56_ WPWQV 61_ SITYE 66_ GVHVC 71_ GGSLV 76_ SEQWV 81_ LSAAH 86_ CFPSE 91_ HHKEA 96_ YEVKL 101_ GAHQL 106_ DSYSE 111_ DAKVS 116_ TLKDI 121_ IPHPS 126_ YLQEG 131_ SQGDI 136_ ALLQL 141_ SRPIT 146_ FSRYI 151_ RPICL 156_ PAANA 161_ SFPNG 166_ LHCTV 171_ TGWGH 176_ VAPSV 181_ SLLTP 186_ KPLQQ 191_ LEVPL 196_ ISRET 201_ CNCLY 206_ NIDAK 211_ PEEPH 216_ FVQED 221_ MVCAG 226_ YVEGG 231_ KDACQ 236_ GDSGG 241_ PLSCP 246_ VEGLW 251_ YLTGI 256_ VSWGD 261_ ACGAR 266_ NRPGV 271_ YTLAS 276_ SYASW 281_ IQSKV 286_ TELQP 291_ RVVPQ 296_ TQESQ 301_ PDSNL 306_ CGSHL 311_ AFSSA 316_ PAQGL 321_ LRPIL 326_ FLPLG 331_ LALGL 336_LSPWL
1: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G)