[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)
1_MKAAR 6_ FVLRS 11_ AGSLN 16_ GAGLV 21_ PREVE 26_ HFSRY 31_ SPSPL 36_ SMKQL 41_ LDFGS 46_ ENACE 51_ RTSFA 56_ FLRQE 61_ LPVRL 66_ ANILK 71_ EIDIL 76_ PTQLV 81_ NTSSV 86_ QLVKS 91_ WYIQS 96_ LMDLV 101_ EFHEK 106_ SPDDQ 111_ KALSD 116_ FVDTL 121_ IKVRN 126_ RHHNV 131_ VPTMA 136_ QGIIE 141_ YKDAC 146_ TVDPV 151_ TNQNL 156_ QYFLD 161_ RFYMN 166_ RISTR 171_ MLMNQ 176_ HILIF 181_ SDSQT 186_ GNPSH 191_ IGSID 196_ PNCDV 201_ VAVVQ 206_ DAFEC 211_ SRMLC 216_ DQYYL 221_ SSPEL 226_ KLTQV 231_ NGKFP 236_ DQPIH 241_ IVYVP 246_ SHLHH 251_ MLFEL 256_ FKNAM 261_ RATVE 266_ HQENQ 271_ PSLTP 276_ IEVIV 281_ VLGKE 286_ DLTIK 291_ ISDRG 296_ GGVPL 301_ RIIDR 306_ LFSYT 311_ YSTAP 316_ TPVMD 321_ NSRNA 326_ PLAGF 331_ GYGLP 336_ ISRLY 341_ AKYFQ 346_ GDLNL 351_ YSLSG 356_ YGTDA 361_ IIYLK 366_ ALSSE 371_ SIEKL 376_ PVFNK 381_ SAFKH 386_ YQMSS 391_ EADDW 396_ CIPSR 401_ EPKNL 406_AKEVA
1: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism