Guanylate cyclase activator 2B [Cleaved into: Guanylate cyclase C-activating peptide 2 (Guanylate cyclase C-activating peptide II) (GCAP-II); Uroguanylin (UGN)]
1_MGCRA 6_ ASGLL 11_ PGVAV 16_ VLLLL 21_ LQSTQ 26_ SVYIQ 31_ YQGFR 36_ VQLES 41_ MKKLS 46_ DLEAQ 51_ WAPSP 56_ RLQAQ 61_ SLLPA 66_ VCHHP 71_ ALPQD 76_ LQPVC 81_ ASQEA 86_ SSIFK 91_ TLRTI 96_ ANDDC 101_ ELCVN 106_VACTG
1: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport