Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
1_MEGAG 6_ GANDK 11_ KKISS 16_ ERRKE 21_ KSRDA 26_ ARSRR 31_ SKESE 36_ VFYEL 41_ AHQLP 46_ LPHNV 51_ SSHLD 56_ KASVM 61_ RLTIS 66_ YLRVR 71_ KLLDA 76_ GDLDI 81_ EDDMK 86_ AQMNC 91_ FYLKA 96_ LDGFV 101_ MVLTD 106_ DGDMI 111_ YISDN 116_ VNKYM 121_ GLTQF 126_ ELTGH 131_ SVFDF 136_ THPCD 141_ HEEMR 146_ EMLTH 151_ RNGLV 156_ KKGKE 161_ QNTQR 166_ SFFLR 171_ MKCTL 176_ TSRGR 181_ TMNIK 186_ SATWK 191_ VLHCT 196_ GHIHV 201_ YDTNS 206_ NQPQC 211_ GYKKP 216_ PMTCL 221_ VLICE 226_ PIPHP 231_ SNIEI 236_ PLDSK 241_ TFLSR 246_ HSLDM 251_ KFSYC 256_ DERIT 261_ ELMGY 266_ EPEEL 271_ LGRSI 276_ YEYYH 281_ ALDSD 286_ HLTKT 291_ HHDMF 296_ TKGQV 301_ TTGQY 306_ RMLAK 311_ RGGYV 316_ WVETQ 321_ ATVIY 326_ NTKNS 331_ QPQCI 336_ VCVNY 341_ VVSGI 346_ IQHDL 351_ IFSLQ 356_ QTECV 361_ LKPVE 366_ SSDMK 371_ MTQLF 376_ TKVES 381_ EDTSS 386_ LFDKL 391_ KKEPD 396_ ALTLL 401_ APAAG 406_ DTIIS 411_ LDFGS 416_ NDTET 421_ DDQQL 426_ EEVPL 431_ YNDVM 436_ LPSPN 441_ EKLQN 446_ INLAM 451_ SPLPT 456_ AETPK 461_ PLRSS 466_ ADPAL 471_ NQEVA 476_ LKLEP 481_ NPESL 486_ ELSFT 491_ MPQIQ 496_ DQTPS 501_ PSDGS 506_ TRQSS 511_ PEPNS 516_ PSEYC 521_ FYVDS 526_ DMVNE 531_ FKLEL 536_ VEKLF 541_ AEDTE 546_ AKNPF 551_ STQDT 556_ DLDLE 561_ MLAPY 566_ IPMDD 571_ DFQLR 576_ SFDQL 581_ SPLES 586_ SSASP 591_ ESASP 596_ QSTVT 601_ VFQQT 606_ QIQEP 611_ TANAT 616_ TTTAT 621_ TDELK 626_ TVTKD 631_ RMEDI 636_ KILIA 641_ SPSPT 646_ HIHKE 651_ TTSAT 656_ SSPYR 661_ DTQSR 666_ TASPN 671_ RAGKG 676_ VIEQT 681_ EKSHP 686_ RSPNV 691_ LSVAL 696_ SQRTT 701_ VPEEE 706_ LNPKI 711_ LALQN 716_ AQRKR 721_ KMEHD 726_ GSLFQ 731_ AVGIG 736_ TLLQQ 741_ PDDHA 746_ ATTSL 751_ SWKRV 756_ KGCKS 761_ SEQNG 766_ MEQKT 771_ IILIP 776_ SDLAC 781_ RLLGQ 786_ SMDES 791_ GLPQL 796_ TSYDC 801_ EVNAP 806_ IQGSR 811_ NLLQG 816_ EELLR 821_ALDQV
1: Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298)
2: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943)