Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase)
1_MALLD 6_ LALEG 11_ MAVFG 16_ FVLFL 21_ VLWLM 26_ HFMAI 31_ IYTRL 36_ HLNKK 41_ ATDKQ 46_ PYSKL 51_ PGVSL 56_ LKPLK 61_ GVDPN 66_ LINNL 71_ ETFFE 76_ LDYPK 81_ YEVLL 86_ CVQDH 91_ DDPAI 96_ DVCKK 101_ LLGKY 106_ PNVDA 111_ RLFIG 116_ GKKVG 121_ INPKI 126_ NNLMP 131_ GYEVA 136_ KYDLI 141_ WICDS 146_ GIRVI 151_ PDTLT 156_ DMVNQ 161_ MTEKV 166_ GLVHG 171_ LPYVA 176_ DRQGF 181_ AATLE 186_ QVYFG 191_ TSHPR 196_ YYISA 201_ NVTGF 206_ KCVTG 211_ MSCLM 216_ RKDVL 221_ DQAGG 226_ LIAFA 231_ QYIAE 236_ DYFMA 241_ KAIAD 246_ RGWRF 251_ AMSTQ 256_ VAMQN 261_ SGSYS 266_ ISQFQ 271_ SRMIR 276_ WTKLR 281_ INMLP 286_ ATIIC 291_ EPISE 296_ CFVAS 301_ LIIGW 306_ AAHHV 311_ FRWDI 316_ MVFFM 321_ CHCLA 326_ WFIFD 331_ YIQLR 336_ GVQGG 341_ TLCFS 346_ KLDYA 351_ VAWFI 356_ RESMT 361_ IYIFL 366_ SALWD 371_ PTISW 376_ RTGRY 381_ RLRCG 386_GTAEE
1: Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi (PubMed:1532799, PubMed:8643456). Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) (PubMed:1532799, PubMed:8643456). GlcCer is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:8643456). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction, implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity). They are required for instance in the proper development and functioning of the nervous system (By similarity). As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (By similarity). They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (By similarity). The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (PubMed:33361282)