ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp)
1_MWPGI 6_ LVGGA 11_ RVASC 16_ RYPAL 21_ GPRLA 26_ AHFPA 31_ QRPPQ 36_ RTLQN 41_ GLALQ 46_ RCLHA 51_ TATRA 56_ LPLIP 61_ IVVEQ 66_ TGRGE 71_ RAYDI 76_ YSRLL 81_ RERIV 86_ CVMGP 91_ IDDSV 96_ ASLVI 101_ AQLLF 106_ LQSES 111_ NKKPI 116_ HMYIN 121_ SPGGV 126_ VTAGL 131_ AIYDT 136_ MQYIL 141_ NPICT 146_ WCVGQ 151_ AASMG 156_ SLLLA 161_ AGTPG 166_ MRHSL 171_ PNSRI 176_ MIHQP 181_ SGGAR 186_ GQATD 191_ IAIQA 196_ EEIMK 201_ LKKQL 206_ YNIYA 211_ KHTKQ 216_ SLQVI 221_ ESAME 226_ RDRYM 231_ SPMEA 236_ QEFGI 241_ LDKVL 246_ VHPPQ 251_ DGEDE 256_ PTLVQ 261_ KEPVE 266_ AAPAA 271_EPVPA
1: Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782). Cleaves PINK1 in the mitochondrion (PubMed:22354088)