Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)
1_MAGGR 6_ HRRVV 11_ GTLHL 16_ LLLVA 21_ ALPWA 26_ SRGVS 31_ PSASA 36_ WPEEK 41_ NYHQP 46_ AILNS 51_ SALRQ 56_ IAEGT 61_ SISEM 66_ WQNDL 71_ QPLLI 76_ ERYPG 81_ SPGSY 86_ AARQH 91_ IMQRI 96_ QRLQA 101_ DWVLE 106_ IDTFL 111_ SQTPY 116_ GYRSF 121_ SNIIS 126_ TLNPT 131_ AKRHL 136_ VLACH 141_ YDSKY 146_ FSHWN 151_ NRVFV 156_ GATDS 161_ AVPCA 166_ MMLEL 171_ ARALD 176_ KKLLS 181_ LKTVS 186_ DSKPD 191_ LSLQL 196_ IFFDG 201_ EEAFL 206_ HWSPQ 211_ DSLYG 216_ SRHLA 221_ AKMAS 226_ TPHPP 231_ GARGT 236_ SQLHG 241_ MDLLV 246_ LLDLI 251_ GAPNP 256_ TFPNF 261_ FPNSA 266_ RWFER 271_ LQAIE 276_ HELHE 281_ LGLLK 286_ DHSLE 291_ GRYFQ 296_ NYSYG 301_ GVIQD 306_ DHIPF 311_ LRRGV 316_ PVLHL 321_ IPSPF 326_ PEVWH 331_ TMDDN 336_ EENLD 341_ ESTID 346_ NLNKI 351_ LQVFV 356_LEYLH
1: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides