Glutathione S-transferase A3 (EC 2.5.1.18) (GST class-alpha member 3) (Glutathione S-transferase A3-3)
1_MAGKP 6_ KLHYF 11_ NGRGR 16_ MEPIR 21_ WLLAA 26_ AGVEF 31_ EEKFI 36_ GSAED 41_ LGKLR 46_ NDGSL 51_ MFQQV 56_ PMVEI 61_ DGMKL 66_ VQTRA 71_ ILNYI 76_ ASKYN 81_ LYGKD 86_ IKERA 91_ LIDMY 96_ TEGMA 101_ DLNEM 106_ ILLLP 111_ LCRPE 116_ EKDAK 121_ IALIK 126_ EKTKS 131_ RYFPA 136_ FEKVL 141_ QSHGQ 146_ DYLVG 151_ NKLSR 156_ ADISL 161_ VELLY 166_ YVEEL 171_ DSSLI 176_ SNFPL 181_ LKALK 186_ TRISN 191_ LPTVK 196_ KFLQP 201_ GSPRK 206_ PPADA 211_ KALEE 216_ARKIF
1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity)