Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase 1) (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I)
1_MAKQL 6_ QARRL 11_ DGIDY 16_ NPWVE 21_ FVKLA 26_ SEHDV 31_ VNLGQ 36_ GFPDF 41_ PPPDF 46_ AVEAF 51_ QHAVS 56_ GDFML 61_ NQYTK 66_ TFGYP 71_ PLTKI 76_ LASFF 81_ GELLG 86_ QEIDP 91_ LRNVL 96_ VTVGG 101_ YGALF 106_ TAFQA 111_ LVDEG 116_ DEVII 121_ IEPFF 126_ DCYEP 131_ MTMMA 136_ GGRPV 141_ FVSLK 146_ PGPIQ 151_ NGELG 156_ SSSNW 161_ QLDPM 166_ ELAGK 171_ FTSRT 176_ KALVL 181_ NTPNN 186_ PLGKV 191_ FSREE 196_ LELVA 201_ SLCQQ 206_ HDVVC 211_ ITDEV 216_ YQWMV 221_ YDGHQ 226_ HISIA 231_ SLPGM 236_ WERTL 241_ TIGSA 246_ GKTFS 251_ ATGWK 256_ VGWVL 261_ GPDHI 266_ MKHLR 271_ TVHQN 276_ SVFHC 281_ PTQSQ 286_ AAVAE 291_ SFERE 296_ QLLFR 301_ QPSSY 306_ FVQFP 311_ QAMQR 316_ CRDHM 321_ IRSLQ 326_ SVGLK 331_ PIIPQ 336_ GSYFL 341_ ITDIS 346_ DFKRK 351_ MPDLP 356_ GAVDE 361_ PYDRR 366_ FVKWM 371_ IKNKG 376_ LVAIP 381_ VSIFY 386_ SVPHQ 391_ KHFDH 396_ YIRFC 401_ FVKDE 406_ ATLQA 411_ MDEKL 416_RKWKV
1: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047)