Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1)
1_MSGPR 6_ PVVLS 11_ GPSGA 16_ GKSTL 21_ LKRLL 26_ QEHSG 31_ IFGFS 36_ VSHTT 41_ RNPRP 46_ GEENG 51_ KDYYF 56_ VTREV 61_ MQRDI 66_ AAGDF 71_ IEHAE 76_ FSGNL 81_ YGTSK 86_ VAVQA 91_ VQAMN 96_ RICVL 101_ DVDLQ 106_ GVRNI 111_ KATDL 116_ RPIYI 121_ SVQPP 126_ SLHVL 131_ EQRLR 136_ QRNTE 141_ TEESL 146_ VKRLA 151_ AAQAD 156_ MESSK 161_ EPGLF 166_ DVVII 171_ NDSLD 176_ QAYAE 181_ LKEAL 186_ SEEIK 191_KAQRT
1: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664)