Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta)
1_MDLWN 6_ LSWFL 11_ FLDAL 16_ LVISG 21_ LATPE 26_ NFDVD 31_ GGMDQ 36_ DIFDI 41_ NEGLG 46_ LDLFE 51_ GDIRL 56_ DRAQI 61_ RNSII 66_ GEKYR 71_ WPHTI 76_ PYVLE 81_ DSLEM 86_ NAKGV 91_ ILNAF 96_ ERYRL 101_ KTCID 106_ FKPWA 111_ GETNY 116_ ISVFK 121_ GSGCW 126_ SSVGN 131_ RRVGK 136_ QELSI 141_ GANCD 146_ RIATV 151_ QHEFL 156_ HALGF 161_ WHEQS 166_ RSDRD 171_ DYVRI 176_ MWDRI 181_ LSGRE 186_ HNFNT 191_ YSDDI 196_ SDSLN 201_ VPYDY 206_ TSVMH 211_ YSKTA 216_ FQNGT 221_ EPTIV 226_ TRISD 231_ FEDVI 236_ GQRMD 241_ FSDSD 246_ LLKLN 251_ QLYNC 256_ SSSLS 261_ FMDSC 266_ SFELE 271_ NVCGM 276_ IQSSG 281_ DNADW 286_ QRVSQ 291_ VPRGP 296_ ESDHS 301_ NMGQC 306_ QGSGF 311_ FMHFD 316_ SSSVN 321_ VGATA 326_ VLESR 331_ TLYPK 336_ RGFQC 341_ LQFYL 346_ YNSGS 351_ ESDQL 356_ NIYIR 361_ EYSAD 366_ NVDGN 371_ LTLVE 376_ EIKEI 381_ PTGSW 386_ QLYHV 391_ TLKVT 396_ KKFRV 401_ VFEGR 406_ KGSGA 411_ SLGGL 416_ SIDDI 421_ NLSET 426_ RCPHH 431_ IWHIR 436_ NFTQF 441_ IGSPN 446_ GTLYS 451_ PPFYS 456_ SKGYA 461_ FQIYL 466_ NLAHV 471_ TNAGI 476_ YFHLI 481_ SGAND 486_ DQLQW 491_ PCPWQ 496_ QATMT 501_ LLDQN 506_ PDIRQ 511_ RMSNQ 516_ RSITT 521_ DPFMT 526_ TDNGN 531_ YFWDR 536_ PSKVG 541_ TVALF 546_ SNGTQ 551_ FRRGG 556_ GYGTS 561_ AFITH 566_ ERLKS 571_ RDFIK 576_ GDDVY 581_ ILLTV 586_ EDISH 591_ LNSTQ 596_ IQLTP 601_ APSVQ 606_ DLCSK 611_ TTCKN 616_ DGVCT 621_ VRDGK 626_ AECRC 631_ QSGED 636_ WWYMG 641_ ERCEK 646_ RGSTR 651_ DTIVI 656_ AVSST 661_ VAVFA 666_ LMLII 671_ TLVSV 676_ YCTRK 681_ KYRER 686_ MSSNR 691_ PNLTP 696_QNQHA
1: Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Also cleaves the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides (PubMed:27180357)