Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
1_MIDTL 6_ RPVPF 11_ ASEMA 16_ ISKTV 21_ AWLNE 26_ QLELG 31_ NERLL 36_ LMDCR 41_ PQELY 46_ ESSHI 51_ ESAIN 56_ VAIPG 61_ IMLRR 66_ LQKGN 71_ LPVRA 76_ LFTRG 81_ EDRDR 86_ FTRRC 91_ GTDTV 96_ VLYDE 101_ SSSDW 106_ NENTG 111_ GESVL 116_ GLLLK 121_ KLKDE 126_ GCRAF 131_ YLEGG 136_ FSKFQ 141_ AEFSL 146_ HCETN 151_ LDGSC 156_ SSSSP 161_ PLPVL 166_ GLGGL 171_ RISSD 176_ SSSDI 181_ ESDLD 186_ RDPNS 191_ ATDSD 196_ GSPLS 201_ NSQPS 206_ FPVEI 211_ LPFLY 216_ LGCAK 221_ DSTNL 226_ DVLEE 231_ FGIKY 236_ ILNVT 241_ PNLPN 246_ LFENA 251_ GEFKY 256_ KQIPI 261_ SDHWS 266_ QNLSQ 271_ FFPEA 276_ ISFID 281_ EARGK 286_ NCGVL 291_ VHCLA 296_ GISRS 301_ VTVTV 306_ AYLMQ 311_ KLNLS 316_ MNDAY 321_ DIVKM 326_ KKSNI 331_ SPNFN 336_ FMGQL 341_ LDFER 346_ TLGLS 351_ SPCDN 356_ RVPAQ 361_ QLYFT 366_ TPSNQ 371_ NVYQV 376_DSLQS
1: Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977)