Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2)
1_MKNQL 6_ RGPPA 11_ RAHMS 16_ TSGAA 21_ AAGGT 26_ RAGSE 31_ PGAGS 36_ GSGAG 41_ TGAGA 46_ ATGAG 51_ AMPCK 56_ SAEWL 61_ QEELE 66_ ARGGA 71_ SLLLL 76_ DCRPH 81_ ELFES 86_ SHIET 91_ AINLA 96_ IPGLM 101_ LRRLR 106_ KGNLP 111_ IRSII 116_ PNHAD 121_ KERFA 126_ TRCKA 131_ ATVLL 136_ YDEAT 141_ AEWQP 146_ EPGAP 151_ ASVLG 156_ LLLQK 161_ LRDDG 166_ CQAYY 171_ LQGGF 176_ NKFQT 181_ EYSEH 186_ CETNV 191_ DSSSS 196_ PSSSP 201_ PTSVL 206_ GLGGL 211_ RISSD 216_ CSDGE 221_ SDREL 226_ PSSAT 231_ ESDGS 236_ PVPSS 241_ QPAFP 246_ VQILP 251_ YLYLG 256_ CAKDS 261_ TNLDV 266_ LGKYG 271_ IKYIL 276_ NVTPN 281_ LPNAF 286_ EHGGE 291_ FTYKQ 296_ IPISD 301_ HWSQN 306_ LSQFF 311_ PEAIS 316_ FIDEA 321_ RSKKC 326_ GVLVH 331_ CLAGI 336_ SRSVT 341_ VTVAY 346_ LMQKM 351_ NLSLN 356_ DAYDF 361_ VKRKK 366_ SNISP 371_ NFNFM 376_ GQLLD 381_ FERTL 386_ GLSSP 391_ CDNHA 396_ SSEQL 401_ YFSTP 406_ TNHNL 411_FPLNT
1: Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity)