Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
1_MILIP 6_ RMLLV 11_ LFLLL 16_ PILSS 21_ AKAQV 26_ NPAIC 31_ RYPLG 36_ MSGGQ 41_ IPDED 46_ ITASS 51_ QWSES 56_ TAAKY 61_ GRLDS 66_ EEGDG 71_ AWCPE 76_ IPVEP 81_ DDLKE 86_ FLQID 91_ LHTLH 96_ FITLV 101_ GTQGR 106_ HAGGH 111_ GIEFA 116_ PMYKI 121_ NYSRD 126_ GTRWI 131_ SWRNR 136_ HGKQV 141_ LDGNS 146_ NPYDI 151_ FLKDL 156_ EPPIV 161_ ARFVR 166_ FIPVT 171_ DHSMN 176_ VCMRV 181_ ELYGC 186_ VWLDG 191_ LVSYN 196_ APAGQ 201_ QFVLP 206_ GGSII 211_ YLNDS 216_ VYDGA 221_ VGYSM 226_ TEGLG 231_ QLTDG 236_ VSGLD 241_ DFTQT 246_ HEYHV 251_ WPGYD 256_ YVGWR 261_ NESAT 266_ NGYIE 271_ IMFEF 276_ DRIRN 281_ FTTMK 286_ VHCNN 291_ MFAKG 296_ VKIFK 301_ EVQCY 306_ FRSEA 311_ SEWEP 316_ NAISF 321_ PLVLD 326_ DVNPS 331_ ARFVT 336_ VPLHH 341_ RMASA 346_ IKCQY 351_ HFADT 356_ WMMFS 361_ EITFQ 366_ SDAAM 371_ YNNSE 376_ ALPTS 381_ PMAPT 386_ TYDPM 391_ LKVDD 396_ SNTRI 401_ LIGCL 406_ VAIIF 411_ ILLAI 416_ IVIIL 421_ WRQFW 426_ QKMLE 431_ KASRR 436_ MLDDE 441_ MTVSL 446_ SLPSD 451_ SSMFN 456_ NNRSS 461_ SPSEQ 466_ GSNST 471_ YDRIF 476_ PLRPD 481_ YQEPS 486_ RLIRK 491_ LPEFA 496_ PGEEE 501_ SGCSG 506_ VVKPV 511_ QPSGP 516_ EGVPH 521_ YAEAD 526_ IVNLQ 531_ GVTGG 536_ NTYSV 541_ PAVTM 546_ DLLSG 551_ KDVAV 556_ EEFPR 561_ KLLTF 566_ KEKLG 571_ EGQFG 576_ EVHLC 581_ EVEGM 586_ EKFKD 591_ KDFAL 596_ DVSAN 601_ QPVLV 606_ AVKML 611_ RADAN 616_ KNARN 621_ DFLKE 626_ IKIMS 631_ RLKDP 636_ NIIHL 641_ LAVCI 646_ TDDPL 651_ CMITE 656_ YMENG 661_ DLNQF 666_ LSRHE 671_ PPNSS 676_ SSDVR 681_ TVSYT 686_ NLKFM 691_ ATQIA 696_ SGMKY 701_ LSSLN 706_ FVHRD 711_ LATRN 716_ CLVGK 721_ NYTIK 726_ IADFG 731_ MSRNL 736_ YSGDY 741_ YRIQG 746_ RAVLP 751_ IRWMS 756_ WESIL 761_ LGKFT 766_ TASDV 771_ WAFGV 776_ TLWET 781_ FTFCQ 786_ EQPYS 791_ QLSDE 796_ QVIEN 801_ TGEFF 806_ RDQGR 811_ QTYLP 816_ QPAIC 821_ PDSVY 826_ KLMLS 831_ CWRRD 836_ TKNRP 841_ SFQEI 846_HLLLL
1: Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing