Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)
1_MAFVT 6_ RQFMR 11_ SVSSS 16_ STASA 21_ SAKKI 26_ IVKHV 31_ TVIGG 36_ GLMGA 41_ GIAQV 46_ AAATG 51_ HTVVL 56_ VDQTE 61_ DILAK 66_ SKKGI 71_ EESLR 76_ KVAKK 81_ KFAEN 86_ LKAGD 91_ EFVEK 96_ TLSTI 101_ ATSTD 106_ AASVV 111_ HSTDL 116_ VVEAI 121_ VENLK 126_ VKNEL 131_ FKRLD 136_ KFAAE 141_ HTIFA 146_ SNTSS 151_ LQITS 156_ IANAT 161_ TRQDR 166_ FAGLH 171_ FFNPV 176_ PVMKL 181_ VEVIK 186_ TPMTS 191_ QKTFE 196_ SLVDF 201_ SKALG 206_ KHPVS 211_ CKDTP 216_ GFIVN 221_ RLLVP 226_ YLMEA 231_ IRLYE 236_ RGDAS 241_ KEDID 246_ TAMKL 251_ GAGYP 256_ MGPFE 261_ LLDYV 266_ GLDTT 271_ KFIVD 276_ GWHEM 281_ DAENP 286_ LHQPS 291_ PSLNK 296_ LVAEN 301_ KFGKK 306_TGEGF
1: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity)