CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (Alpha 2,3-ST 2) (Beta-galactoside alpha-2,3-sialyltransferase 2) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.99.2) (ST3Gal II) (ST3GalII) (ST3GalA.2) (Sialyltransferase 4B) (SIAT4-B)
1_MKCSL 6_ RVWFL 11_ SVAFL 16_ LVFIM 21_ SLLFT 26_ YSHHS 31_ MATLP 36_ YLDSG 41_ ALDGT 46_ HRVKL 51_ VPGYA 56_ GLQRL 61_ SKERL 66_ SGKSC 71_ ACRRC 76_ MGDAG 81_ ASDWF 86_ DSHFD 91_ GNISP 96_ VWTRE 101_ NMDLP 106_ PDVQR 111_ WWMML 116_ QPQFK 121_ SHNTN 126_ EVLEK 131_ LFQIV 136_ PGENP 141_ YRFRD 146_ PHQCR 151_ RCAVV 156_ GNSGN 161_ LRGSG 166_ YGQDV 171_ DGHNF 176_ IMRMN 181_ QAPTV 186_ GFEQD 191_ VGSRT 196_ THHFM 201_ YPESA 206_ KNLPA 211_ NVSFV 216_ LVPFK 221_ VLDLL 226_ WIASA 231_ LSTGQ 236_ IRFTY 241_ APVKS 246_ FLRVD 251_ KEKVQ 256_ IYNPA 261_ FFKYI 266_ HDRWT 271_ EHHGR 276_ YPSTG 281_ MLVLF 286_ FALHV 291_ CDEVN 296_ VYGFG 301_ ADSRG 306_ NWHHY 311_ WENNR 316_ YAGEF 321_ RKTGV 326_ HDADF 331_ EAHII 336_ DMLAK 341_ASKIE
1: A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:25916169, PubMed:8920913, PubMed:9266697). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:25916169, PubMed:9266697)