Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
1_MRRPR 6_ RPGGL 11_ GGSGG 16_ LRLLL 21_ CLLLL 26_ SSRPG 31_ GCSAV 36_ SAHGC 41_ LFDRR 46_ LCSHL 51_ EVCIQ 56_ DGLFG 61_ QCQVG 66_ VGQAR 71_ PLLQV 76_ TSPVL 81_ QRLQG 86_ VLRQL 91_ MSQGL 96_ SWHDD 101_ LTQYV 106_ ISQEM 111_ ERIPR 116_ LRPPE 121_ PRPRD 126_ RSGLA 131_ PKRPG 136_ PAGEL 141_ LLQDI 146_ PTGSA 151_ PAAQH 156_ RLPQP 161_ PVGKG 166_ GAGAS 171_ SSLSP 176_ LQAEL 181_ LPPLL 186_ EHLLL 191_ PPQPP 196_ HPSLS 201_ YEPAL 206_ LQPYL 211_ FHQFG 216_ SRDGS 221_ RVSEG 226_ SPGMV 231_ SVGPL 236_ PKAEA 241_ PALFS 246_ RTASK 251_ GIFGD 256_ HPGHS 261_ YGDLP 266_ GPSPA 271_ QLFQD 276_ SGLLY 281_ LAQEL 286_ PAPSR 291_ ARVPR 296_ LPEQG 301_ SSSRA 306_ EDSPE 311_ GYEKE 316_ GLGDR 321_ GEKPA 326_ SPAVQ 331_ PDAAL 336_ QRLAA 341_ VLAGY 346_ GVELR 351_ QLTPE 356_ QLSTL 361_ LTLLQ 366_ LLPKG 371_ AGRNP 376_ GGVVN 381_ VGADI 386_ KKTME 391_ GPVEG 396_ RDTAE 401_ LPART 406_ SPMPG 411_ HPTAS 416_ PTSSE 421_ VQQVP 426_ SPVSS 431_ EPPKA 436_ ARPPV 441_ TPVLL 446_ EKKSP 451_ LGQSQ 456_ PTVAG 461_ QPSAR 466_ PAAEE 471_ YGYIV 476_ TDQKP 481_ LSLAA 486_ GVKLL 491_ EILAE 496_ HVHMS 501_ SGSFI 506_ NISVV 511_ GPALT 516_ FRIRH 521_ NEQNL 526_ SLADV 531_ TQQAG 536_ LVKSE 541_ LEAQT 546_ GLQIL 551_ QTGVG 556_ QREEA 561_ AAVLP 566_ QTAHS 571_ TSPMR 576_ SVLLT 581_ LVALA 586_ GVAGL 591_ LVALA 596_ VALCV 601_ RQHAR 606_ QQDKE 611_ RLAAL 616_ GPEGA 621_ HGDTT 626_ FEYQD 631_ LCRQH 636_ MATKS 641_ LFNRA 646_ EGPPE 651_ PSRVS 656_ SVSSQ 661_ FSDAA 666_ QASPS 671_ SHSST 676_ PSWCE 681_ EPAQA 686_ NMDIS 691_ TGHMI 696_ LAYME 701_ DHLRN 706_ RDRLA 711_ KEWQA 716_ LCAYQ 721_ AEPNT 726_ CATAQ 731_ GEGNI 736_ KKNRH 741_ PDFLP 746_ YDHAR 751_ IKLKV 756_ ESSPS 761_ RSDYI 766_ NASPI 771_ IEHDP 776_ RMPAY 781_ IATQG 786_ PLSHT 791_ IADFW 796_ QMVWE 801_ SGCTV 806_ IVMLT 811_ PLVED 816_ GVKQC 821_ DRYWP 826_ DEGAS 831_ LYHVY 836_ EVNLV 841_ SEHIW 846_ CEDFL 851_ VRSFY 856_ LKNVQ 861_ TQETR 866_ TLTQF 871_ HFLSW 876_ PAEGT 881_ PASTR 886_ PLLDF 891_ RRKVN 896_ KCYRG 901_ RSCPI 906_ IVHCS 911_ DGAGR 916_ TGTYI 921_ LIDMV 926_ LNRMA 931_ KGVKE 936_ IDIAA 941_ TLEHV 946_ RDQRP 951_ GLVRS 956_ KDQFE 961_ FALTA 966_ VAEEV 971_NAILK
1: Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity)
2: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2
3: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068)