Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1)
1_MNQKT 6_ ILVLL 11_ ILAVI 16_ TIFAL 21_ VCVLL 26_ VGRGG 31_ DGGEP 36_ SQLPH 41_ CPSVS 46_ PSAQP 51_ WTHPG 56_ QSQLF 61_ ADLSR 66_ EELTA 71_ VMRFL 76_ TQRLG 81_ PGLVD 86_ AAQAR 91_ PSDNC 96_ VFSVE 101_ LQLPP 106_ KAAAL 111_ AHLDR 116_ GSPPP 121_ AREAL 126_ AIVFF 131_ GRQPQ 136_ PNVSE 141_ LVVGP 146_ LPHPS 151_ YMRDV 156_ TVERH 161_ GGPLP 166_ YHRRP 171_ VLFQE 176_ YLDID 181_ QMIFN 186_ RELPQ 191_ ASGLL 196_ HHCCF 201_ YKHRG 206_ RNLVT 211_ MTTAP 216_ RGLQS 221_ GDRAT 226_ WFGLY 231_ YNISG 236_ AGFFL 241_ HHVGL 246_ ELLVN 251_ HKALD 256_ PARWT 261_ IQKVF 266_ YQGRY 271_ YDSLA 276_ QLEAQ 281_ FEAGL 286_ VNVVL 291_ IPDNG 296_ TGGSW 301_ SLKSP 306_ VPPGP 311_ APPLQ 316_ FYPQG 321_ PRFSV 326_ QGSRV 331_ ASSLW 336_ TFSFG 341_ LGAFS 346_ GPRIF 351_ DVRFQ 356_ GERLV 361_ YEISL 366_ QEALA 371_ IYGGN 376_ SPAAM 381_ TTRYV 386_ DGGFG 391_ MGKYT 396_ TPLTR 401_ GVDCP 406_ YLATY 411_ VDWHF 416_ LLESQ 421_ APKTI 426_ RDAFC 431_ VFEQN 436_ QGLPL 441_ RRHHS 446_ DLYSH 451_ YFGGL 456_ AETVL 461_ VVRSM 466_ STLLN 471_ YDYVW 476_ DTVFH 481_ PSGAI 486_ EIRFY 491_ ATGYI 496_ SSAFL 501_ FGATG 506_ KYGNQ 511_ VSEHT 516_ LGTVH 521_ THSAH 526_ FKVDL 531_ DVAGL 536_ ENWVW 541_ AEDMV 546_ FVPMA 551_ VPWSP 556_ EHQLQ 561_ RLQVT 566_ RKLLE 571_ MEEQA 576_ AFLVG 581_ SATPR 586_ YLYLA 591_ SNHSN 596_ KWGHP 601_ RGYRI 606_ QMLSF 611_ AGEPL 616_ PQNSS 621_ MARGF 626_ SWERY 631_ QLAVT 636_ QRKEE 641_ EPSSS 646_ SVFNQ 651_ NDPWA 656_ PTVDF 661_ SDFIN 666_ NETIA 671_ GKDLV 676_ AWVTA 681_ GFLHI 686_ PHAED 691_ IPNTV 696_ TVGNG 701_ VGFFL 706_ RPYNF 711_ FDEDP 716_ SFYSA 721_ DSIYF 726_ RGDQD 731_ AGACE 736_ VNPLA 741_ CLPQA 746_ AACAP 751_ DLPAF 756_SHGGF
1: Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, PubMed:24304424, PubMed:9653080). Has a preference for the primary monoamines methylamine and benzylamine (PubMed:19588076, PubMed:9653080). Could also act on 2-phenylethylamine but much less efficiently (PubMed:19588076). At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion (PubMed:9254657, PubMed:9653080)
2: Has no semicarbazide-sensitive amine oxidase (SSAO) activity