Deoxyguanosine kinase, mitochondrial (EC 2.7.1.113) (Deoxyadenosine kinase, mitochondrial) (EC 2.7.1.76)
1_MAAGR 6_ LFLSR 11_ LRAPF 16_ SSMAK 21_ SPLEG 26_ VSSSR 31_ GLHAG 36_ RGPRR 41_ LSIEG 46_ NIAVG 51_ KSTFV 56_ KLLTK 61_ TYPEW 66_ HVATE 71_ PVATW 76_ QNIQA 81_ AGTQK 86_ ACTAQ 91_ SLGNL 96_ LDMMY 101_ REPAR 106_ WSYTF 111_ QTFSF 116_ LSRLK 121_ VQLEP 126_ FPEKL 131_ LQARK 136_ PVQIF 141_ ERSVY 146_ SDRYI 151_ FAKNL 156_ FENGS 161_ LSDIE 166_ WHIYQ 171_ DWHSF 176_ LLWEF 181_ ASRIT 186_ LHGFI 191_ YLQAS 196_ PQVCL 201_ KRLYQ 206_ RAREE 211_ EKGIE 216_ LAYLE 221_ QLHGQ 226_ HEAWL 231_ IHKTT 236_ KLHFE 241_ ALMNI 246_ PVLVL 251_ DVNDD 256_ FSEEV 261_ TKQED 266_ LMREV 271_NTFVK
1: Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:11687801, PubMed:17073823, PubMed:23043144, PubMed:8692979, PubMed:8706825). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents