Leukotriene C4 synthase (LTC4 synthase) (EC 4.4.1.20) (Glutathione S-transferase LTC4) (EC 2.5.1.-) (Leukotriene-C(4) synthase) (Leukotriene-C4 synthase)
1_MKDEV 6_ ALLAA 11_ VTLLG 16_ VLLQA 21_ YFSLQ 26_ VISAR 31_ RAFRV 36_ SPPLT 41_ TGPPE 46_ FERVY 51_ RAQVN 56_ CSEYF 61_ PLFLA 66_ TLWVA 71_ GIFFH 76_ EGAAA 81_ LCGLV 86_ YLFAR 91_ LRYFQ 96_ GYARS 101_ AQLRL 106_ APLYA 111_ SARAL 116_ WLLVA 121_ LAALG 126_ LLAHF 131_ LPAAL 136_ RAALL 141_GRLRT
1: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:23409838, PubMed:27365393, PubMed:27791009, PubMed:7937884, PubMed:9153254). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009)