Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)
1_MGCAE 6_ GKAVA 11_ AAAPT 16_ ELQTK 21_ GKNGD 26_ GRRRS 31_ AKDHH 36_ PGKTL 41_ PENPA 46_ GFTST 51_ ATADS 56_ RALLQ 61_ AYIDG 66_ HSVVI 71_ FSRST 76_ CTRCT 81_ EVKKL 86_ FKSLC 91_ VPYFV 96_ LELDQ 101_ TEDGR 106_ ALEGT 111_ LSELA 116_ AETDL 121_ PVVFV 126_ KQRKI 131_ GGHGP 136_ TLKAY 141_ QEGRL 146_ QKLLK 151_ MNGPE 156_ DLPKS 161_ YDYDL 166_ IIIGG 171_ GSGGL 176_ AAAKE 181_ AAQYG 186_ KKVMV 191_ LDFVT 196_ PTPLG 201_ TRWGL 206_ GGTCV 211_ NVGCI 216_ PKKLM 221_ HQAAL 226_ LGQAL 231_ QDSRN 236_ YGWKV 241_ EETVK 246_ HDWDR 251_ MIEAV 256_ QNHIG 261_ SLNWG 266_ YRVAL 271_ REKKV 276_ VYENA 281_ YGQFI 286_ GPHRI 291_ KATNN 296_ KGKEK 301_ IYSAE 306_ RFLIA 311_ TGERP 316_ RYLGI 321_ PGDKE 326_ YCISS 331_ DDLFS 336_ LPYCP 341_ GKTLV 346_ VGASY 351_ VALEC 356_ AGFLA 361_ GIGLD 366_ VTVMV 371_ RSILL 376_ RGFDQ 381_ DMANK 386_ IGEHM 391_ EEHGI 396_ KFIRQ 401_ FVPIK 406_ VEQIE 411_ AGTPG 416_ RLRVV 421_ AQSTN 426_ SEEII 431_ EGEYN 436_ TVMLA 441_ IGRDA 446_ CTRKI 451_ GLETV 456_ GVKIN 461_ EKTGK 466_ IPVTD 471_ EEQTN 476_ VPYIY 481_ AIGDI 486_ LEDKV 491_ ELTPV 496_ AIQAG 501_ RLLAQ 506_ RLYAG 511_ STVKC 516_ DYENV 521_ PTTVF 526_ TPLEY 531_ GACGL 536_ SEEKA 541_ VEKFG 546_ EENIE 551_ VYHSY 556_ FWPLE 561_ WTIPS 566_ RDNNK 571_ CYAKI 576_ ICNTK 581_ DNERV 586_ VGFHV 591_ LGPNA 596_ GEVTQ 601_ GFAAA 606_ LKCGL 611_ TKKQL 616_ DSTIG 621_ IHPVC 626_ AEVFT 631_ TLSVT 636_ KRSGA 641_SILQA
1: Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437)
2: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions
3: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2
4: Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665)