Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2)
1_MKKQF 6_ NRMRQ 11_ LANQT 16_ VGRAE 21_ KTEVL 26_ SEDLL 31_ QVEKR 36_ LELVK 41_ QVSHS 46_ THKKL 51_ TACLQ 56_ GQQGA 61_ EADKR 66_ SKKLP 71_ LTTLA 76_ QCLME 81_ GSAIL 86_ GDDTL 91_ LGKML 96_ KLCGE 101_ TEDKL 106_ AQELI 111_ HFELQ 116_ VERDV 121_ IEPLF 126_ LLAEV 131_ EIPNI 136_ QKQRK 141_ HLAKL 146_ VLDMD 151_ SSRTR 156_ WQQTS 161_ KSSGL 166_ SSSLQ 171_ PAGAK 176_ ADALR 181_ EEMEE 186_ AANRV 191_ EICRD 196_ QLSAD 201_ MYSFV 206_ AKEID 211_ YANYF 216_ QTLIE 221_ VQAEY 226_ HRKSL 231_ TLLQA 236_ VLPQI 241_ KAQQE 246_ AWVEK 251_ PSFGK 256_ PLEEH 261_ LTISG 266_ REIAF 271_ PIEAC 276_ VTMLL 281_ ECGMQ 286_ EEGLF 291_ RVAPS 296_ ASKLK 301_ KLKAA 306_ LDCCV 311_ VDVQE 316_ YSADP 321_ HAIAG 326_ ALKSY 331_ LRELP 336_ EPLMT 341_ FELYD 346_ EWIQA 351_ SNVQE 356_ QDKKL 361_ QALWN 366_ ACEKL 371_ PKANH 376_ NNIRY 381_ LIKFL 386_ SKLSE 391_ YQDVN 396_ KMTPS 401_ NMAIV 406_ LGPNL 411_ LWPQA 416_ EGNIT 421_ EMMTT 426_ VSLQI 431_ VGIIE 436_ PIIQH 441_ ADWFF 446_ PGEIE 451_ FNITG 456_ NYGSP 461_ VHVNH 466_ NANYS 471_ SMPSP 476_ DMDPA 481_ DRRQP 486_ EQARR 491_ PLSVA 496_ TDNMM 501_ LEFYK 506_ KDGLR 511_ KIQSM 516_ GVRVM 521_ DTNWV 526_ ARRGS 531_ SAGRK 536_ VSCAP 541_ PSMQP 546_ PAPPA 551_ ELAAP 556_ LPSPL 561_ PEQPL 566_ DSPAA 571_ PALSP 576_ SGLGL 581_ QPGPE 586_ RTSTT 591_ KSKEL 596_ SPGSA 601_ QKGSP 606_ GSSQG 611_ TACAG 616_ TQPGA 621_ QPGAQ 626_ PGASP 631_ SPSQP 636_ PADQS 641_ PHTLR 646_ KVSKK 651_ LAPIP 656_ PKVPF 661_ GQPGA 666_ MADQS 671_ AGQPS 676_ PVSLS 681_ PTPPS 686_ TPSPY 691_ GLSYP 696_ QGYSL 701_ ASGQL 706_ SPAAA 711_ PPLAS 716_ PSVFT 721_ STLSK 726_ SRPTP 731_ KPRQR 736_ PTLPP 741_ PQPPT 746_ VNLSA 751_ SSPQS 756_ TEAPM 761_ LDGMS 766_ PGESM 771_ STDLV 776_ HFDIP 781_ SIHIE 786_ LGSTL 791_ RLSPL 796_ EHMRR 801_ HSVTD 806_ KRDSE 811_EESES
1: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity)