Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4)
1_MGDYG 6_ FGVLV 11_ QSNTG 16_ NKSAF 21_ PVRFH 26_ PHLQP 31_ PHHHQ 36_ NATPS 41_ PAAFI 46_ NNNTA 51_ ANGSS 56_ AGSAW 61_ LFPAP 66_ ATHNI 71_ QDEIL 76_ GSEKA 81_ KSQQQ 86_ EQQDP 91_ LEKQQ 96_ LSPSP 101_ GQEAG 106_ ILPET 111_ EKAKS 116_ EENQG 121_ DNSSE 126_ NGNGK 131_ EKIRI 136_ ESPVL 141_ TGFDY 146_ QEATG 151_ LGTST 156_ QPLTS 161_ SASSL 166_ TGFSN 171_ WSAAI 176_ APSSS 181_ TIINE 186_ DASFF 191_ HQGGV 196_ PAASA 201_ NNGAL 206_ LFQNF 211_ PHHVS 216_ PGFGG 221_ SFSPQ 226_ IGPLS 231_ QHHPH 236_ HPHFQ 241_ HHHSQ 246_ HQQQR 251_ RSPAS 256_ PHPPP 261_ FTHRN 266_ AAFNQ 271_ LPHLA 276_ NNLNK 281_ PPSPW 286_ SSYQS 291_ PSPTP 296_ SSSWS 301_ PGGGG 306_ YGGWG 311_ GSQGR 316_ DHRRG 321_ LNGGI 326_ TPLNS 331_ ISPLK 336_ KNFAS 341_ NHIQL 346_ QKYAR 351_ PSSAF 356_ APKSW 361_ MEDSL 366_ NRADN 371_ IFPFP 376_ DRPRT 381_ FDMHS 386_ LESSL 391_ IDIMR 396_ AENDT 401_ IKGRL 406_ NYSYP 411_ GSDSS 416_ LLINA 421_ RTYGR 426_ RRGQS 431_ SLFPM 436_ EDGFL 441_ DDGRG 446_ DQPLH 451_ SGLGS 456_ PHCFS 461_ HQNGE 466_ RVERY 471_ SRKVF 476_ VGGLP 481_ PDIDE 486_ DEITA 491_ SFRRF 496_ GPLIV 501_ DWPHK 506_ AESKS 511_ YFPPK 516_ GYAFL 521_ LFQDE 526_ SSVQA 531_ LIDAC 536_ IEEDG 541_ KLYLC 546_ VSSPT 551_ IKDKP 556_ VQIRP 561_ WNLSD 566_ SDFVM 571_ DGSQP 576_ LDPRK 581_ TIFVG 586_ GVPRP 591_ LRAVE 596_ LAMIM 601_ DRLYG 606_ GVCYA 611_ GIDTD 616_ PELKY 621_ PKGAG 626_ RVAFS 631_ NQQSY 636_ IAAIS 641_ ARFVQ 646_ LQHGE 651_ IDKRV 656_ EVKPY 661_ VLDDQ 666_ LCDEC 671_ QGARC 676_ GGKFA 681_ PFFCA 686_ NVTCL 691_ QYYCE 696_ YCWAA 701_ IHSRA 706_ GREFH 711_ KPLVK 716_ EGGDR 721_PRHIS
1: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity)