S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-)
1_MEPGA 6_ GGRNT 11_ ARAQR 16_ AGSPN 21_ TPPPR 26_ EQERK 31_ LEQEK 36_ LSGVV 41_ KSVHR 46_ RLRKK 51_ YREVG 56_ DFDKI 61_ WREHC 66_ EDEET 71_ LCEYA 76_ VAMKN 81_ LADNH 86_ WAKTC 91_ EGEGR 96_ IEWCC 101_ SVCRE 106_ YFQNG 111_ GKRKA 116_ LEKDE 121_ KRAVL 126_ ATKTT 131_ PALNM 136_ HESSQ 141_ LEGHL 146_ TNLSF 151_ TNPEF 156_ ITELL 161_ QASGK 166_ IRLLD 171_ VGSCF 176_ NPFLK 181_ FEEFL 186_ TVGID 191_ IVPAV 196_ ESVYK 201_ CDFLN 206_ LQLQQ 211_ PLQLA 216_ QDAID 221_ AFLKQ 226_ LKNPI 231_ DSLPG 236_ ELFHV 241_ VVFSL 246_ LLSYF 251_ PSPYQ 256_ RWICC 261_ KKAHE 266_ LLVLN 271_ GLLLI 276_ ITPDS 281_ SHQNR 286_ HAMMM 291_ KSWKI 296_ AIESL 301_ GFKRF 306_ KYSKF 311_ SHMHL 316_ MAFRK 321_ ISLKT 326_ TSDLV 331_ SRNYP 336_ GMLYI 341_ PQDFN 346_ SIEDE 351_ EYSNP 356_ SCYVR 361_ SDIED 366_ EQLAY 371_ GFTEL 376_ PDAPY 381_ DSDSG 386_ ESQAS 391_ SIPFY 396_ELEDP
1: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071, PubMed:35776786). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential)