MHC class I polypeptide-related sequence B (MIC-B)
1_MGLGR 6_ VLLFL 11_ AVAFP 16_ FAPPA 21_ AAAEP 26_ HSLRY 31_ NLMVL 36_ SQDGS 41_ VQSGF 46_ LAEGH 51_ LDGQP 56_ FLRYD 61_ RQKRR 66_ AKPQG 71_ QWAEN 76_ VLGAK 81_ TWDTE 86_ TEDLT 91_ ENGQD 96_ LRRTL 101_ THIKD 106_ QKGGL 111_ HSLQE 116_ IRVCE 121_ IHEDS 126_ STRGS 131_ RHFYY 136_ DGELF 141_ LSQNL 146_ ETQES 151_ TVPQS 156_ SRAQT 161_ LAMNV 166_ TNFWK 171_ EDAMK 176_ TKTHY 181_ RAMQA 186_ DCLQK 191_ LQRYL 196_ KSGVA 201_ IRRTV 206_ PPMVN 211_ VTCSE 216_ VSEGN 221_ ITVTC 226_ RASSF 231_ YPRNI 236_ TLTWR 241_ QDGVS 246_ LSHNT 251_ QQWGD 256_ VLPDG 261_ NGTYQ 266_ TWVAT 271_ RIRQG 276_ EEQRF 281_ TCYME 286_ HSGNH 291_ GTHPV 296_ PSGKA 301_ LVLQS 306_ QRTDF 311_ PYVSA 316_ AMPCF 321_ VIIII 326_ LCVPC 331_ CKKKT 336_ SAAEG 341_ PELVS 346_ LQVLD 351_ QHPVG 356_ TGDHR 361_ DAAQL 366_ GFQPL 371_ MSATG 376_STGST
1: Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production