MHC class I polypeptide-related sequence A (MIC-A)
1_MGLGP 6_ VFLLL 11_ AGIFP 16_ FAPPG 21_ AAAEP 26_ HSLRY 31_ NLTVL 36_ SWDGS 41_ VQSGF 46_ LTEVH 51_ LDGQP 56_ FLRCD 61_ RQKCR 66_ AKPQG 71_ QWAED 76_ VLGNK 81_ TWDRE 86_ TRDLT 91_ GNGKD 96_ LRMTL 101_ AHIKD 106_ QKEGL 111_ HSLQE 116_ IRVCE 121_ IHEDN 126_ STRSS 131_ QHFYY 136_ DGELF 141_ LSQNL 146_ ETKEW 151_ TMPQS 156_ SRAQT 161_ LAMNV 166_ RNFLK 171_ EDAMK 176_ TKTHY 181_ HAMHA 186_ DCLQE 191_ LRRYL 196_ KSGVV 201_ LRRTV 206_ PPMVN 211_ VTRSE 216_ ASEGN 221_ ITVTC 226_ RASGF 231_ YPWNI 236_ TLSWR 241_ QDGVS 246_ LSHDT 251_ QQWGD 256_ VLPDG 261_ NGTYQ 266_ TWVAT 271_ RICQG 276_ EEQRF 281_ TCYME 286_ HSGNH 291_ STHPV 296_ PSGKV 301_ LVLQS 306_ HWQTF 311_ HVSAV 316_ AAAAI 321_ FVIII 326_ FYVRC 331_ CKKKT 336_ SAAEG 341_ PELVS 346_ LQVLD 351_ QHPVG 356_ TSDHR 361_ DATQL 366_ GFQPL 371_ MSDLG 376_STGST
1: Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production (PubMed:10426993)