R-spondin-4 (Roof plate-specific spondin-4) (hRspo4)
1_MRAPL 6_ CLLLL 11_ VAHAV 16_ DMLAL 21_ NRRKK 26_ QVGTG 31_ LGGNC 36_ TGCII 41_ CSEEN 46_ GCSTC 51_ QQRLF 56_ LFIRR 61_ EGIRQ 66_ YGKCL 71_ HDCPP 76_ GYFGI 81_ RGQEV 86_ NRCKK 91_ CGATC 96_ ESCFS 101_ QDFCI 106_ RCKRQ 111_ FYLYK 116_ GKCLP 121_ TCPPG 126_ TLAHQ 131_ NTREC 136_ QGECE 141_ LGPWG 146_ GWSPC 151_ THNGK 156_ TCGSA 161_ WGLES 166_ RVREA 171_ GRAGH 176_ EEAAT 181_ CQVLS 186_ ESRKC 191_ PIQRP 196_ CPGER 201_ SPGQK 206_ KGRKD 211_ RRPRK 216_ DRKLD 221_ RRLDV 226_RPRQP
1: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076)