AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)
1_MKKFF 6_ DSRRE 11_ QGGSG 16_ LGSGS 21_ SGGGG 26_ STSGL 31_ GSGYI 36_ GRVFG 41_ IGRQQ 46_ VTVDE 51_ VLAEG 56_ GFAIV 61_ FLVRT 66_ SNGMK 71_ CALKR 76_ MFVNN 81_ EHDLQ 86_ VCKRE 91_ IQIMR 96_ DLSGH 101_ KNIVG 106_ YIDSS 111_ INNVS 116_ SGDVW 121_ EVLIL 126_ MDFCR 131_ GGQVV 136_ NLMNQ 141_ RLQTG 146_ FTENE 151_ VLQIF 156_ CDTCE 161_ AVARL 166_ HQCKT 171_ PIIHR 176_ DLKVE 181_ NILLH 186_ DRGHY 191_ VLCDF 196_ GSATN 201_ KFQNP 206_ QTEGV 211_ NAVED 216_ EIKKY 221_ TTLSY 226_ RAPEM 231_ VNLYS 236_ GKIIT 241_ TKADI 246_ WALGC 251_ LLYKL 256_ CYFTL 261_ PFGES 266_ QVAIC 271_ DGNFT 276_ IPDNS 281_ RYSQD 286_ MHCLI 291_ RYMLE 296_ PDPDK 301_ RPDIY 306_ QVSYF 311_ SFKLL 316_ KKECP 321_ IPNVQ 326_ NSPIP 331_ AKLPE 336_ PVKAS 341_ EAAAK 346_ KTQPK 351_ ARLTD 356_ PIPTT 361_ ETSIA 366_ PRQRP 371_ KAGQT 376_ QPNPG 381_ ILPIQ 386_ PALTP 391_ RKRAT 396_ VQPPP 401_ QAAGS 406_ SNQPG 411_ LLASV 416_ PQPKP 421_ QAPPS 426_ QPLPQ 431_ TQAKQ 436_ PQAPP 441_ TPQQT 446_ PSTQA 451_ QGLPA 456_ QAQAT 461_ PQHQQ 466_ QLFLK 471_ QQQQQ 476_ QQPPP 481_ AQQQP 486_ AGTFY 491_ QQQQA 496_ QTQQF 501_ QAVHP 506_ ATQKP 511_ AIAQF 516_ PVVSQ 521_ GGSQQ 526_ QLMQN 531_ FYQQQ 536_ QQQQQ 541_ QQQQQ 546_ QLATA 551_ LHQQQ 556_ LMTQQ 561_ AALQQ 566_ KPTMA 571_ AGQQP 576_ QPQPA 581_ AAPQP 586_ APAQE 591_ PAIQA 596_ PVRQQ 601_ PKVQT 606_ TPPPA 611_ VQGQK 616_ VGSLT 621_ PPSSP 626_ KTQRA 631_ GHRRI 636_ LSDVT 641_ HSAVF 646_ GVPAS 651_ KSTQL 656_ LQAAA 661_ AEASL 666_ NKSKS 671_ ATTTP 676_ SGSPR 681_ TSQQN 686_ VYNPS 691_ EGSTW 696_ NPFDD 701_ DNFSK 706_ LTAEE 711_ LLNKD 716_ FAKLG 721_ EGKHP 726_ EKLGG 731_ SAESL 736_ IPGFQ 741_ STQGD 746_ AFATT 751_ SFSAG 756_ TAEKR 761_ KGGQT 766_ VDSGL 771_ PLLSV 776_ SDPFI 781_ PLQVP 786_ DAPEK 791_ LIEGL 796_ KSPDT 801_ SLLLP 806_ DLLPM 811_ TDPFG 816_ STSDA 821_ VIEKA 826_ DVAVE 831_ SLIPG 836_ LEPPV 841_ PQRLP 846_ SQTES 851_ VTSNR 856_ TDSLT 861_ GEDSL 866_ LDCSL 871_ LSNPT 876_ TDLLE 881_ EFAPT 886_ AISAP 891_ VHKAA 896_ EDSNL 901_ ISGFD 906_ VPEGS 911_ DKVAE 916_ DEFDP 921_ IPVLI 926_ TKNPQ 931_ GGHSR 936_ NSSGS 941_ SESSL 946_ PNLAR 951_ SLLLV 956_DQLID
1: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124)
2: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue